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Clinical features and treatment outcomes of isolated secondary central nervous system lymphomas in Miyazaki Prefecture
- Source :
- International Journal of Clinical Oncology. 17:336-340
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Secondary central nervous system lymphoma (SCNSL) without extra-central nervous system (CNS) involvement is characterized by isolated secondary CNS relapse in malignant lymphoma patients. SCNSL is a rare disease, and no standard treatment has yet been established.To elucidate the clinical characteristics and outcomes of SCNSL, we retrospectively analyzed 12 patients (median age 67 years) in Miyazaki prefecture for the last 5 years.The initial histological diagnoses of the patients were diffuse large B-cell lymphoma (DLBCL), mantle-cell lymphoma, and adult T-cell lymphoma in 9, 2, and 1 patient, respectively. We focused on analysis of the 9 SCNSL cases originating from DLBCL. The locations of CNS relapse were the cerebral hemisphere, basal ganglia, and cerebellum in 7, 1, and 1 patient, respectively. Three patients were treated with high-dose methotrexate (HD-MTX) therapy; 4 with whole-brain radiation therapy (WBRTX); and 1 with both HD-MTX and WBRTX. The remaining patients were treated with rituximab. Partial remission was achieved in 6 out of 9 patients (67%); the other 3 patients (33%) did not respond to therapy. Median survival of the 9 patients with CNS relapse was 253 days; 6 of the 9 patients survived for more than 6 months. As of March 2011, 2 HD-MTX group patients but none of the WBRTX group patients were alive.In this retrospective study, 6 of 9 patients with SCNSL originating from DLBCL survived for more than 6 months. Both HD-MTX and WBRTX had clinical benefits in the treatment of SCNSL.
- Subjects :
- Male
Nervous system
Pathology
medicine.medical_specialty
Central nervous system
Lymphoma, T-Cell
Central Nervous System Neoplasms
Antibodies, Monoclonal, Murine-Derived
Recurrence
Surgical oncology
hemic and lymphatic diseases
Antineoplastic Combined Chemotherapy Protocols
Humans
Medicine
Aged
Aged, 80 and over
business.industry
Standard treatment
Hematology
General Medicine
Middle Aged
Prognosis
medicine.disease
Lymphoma
Methotrexate
Treatment Outcome
medicine.anatomical_structure
Oncology
Monoclonal
Female
Surgery
Rituximab
Lymphoma, Large B-Cell, Diffuse
business
medicine.drug
Rare disease
Subjects
Details
- ISSN :
- 14377772 and 13419625
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- International Journal of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....3a831a7181387d132cba0f5d92aabe96