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Castration inhibits glomerular hypertrophy and proteinuria in uninephrectomized male rats
- Source :
- European Journal of Clinical Investigation. 20:360-365
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- Renal mass reduction may lead to glomerular hypertrophy, proteinuria and focal glomerulosclerosis (FGS) in humans and rats. In humans and rats, females are less susceptible than males to these phenomena. This study was undertaken to evaluate the effect of male rat castration on the pathogenesis of proteinuria and FGS. Urinary protein was measured in 60-day-old male and female rats. Uninephrectomy was performed in all rats, and castration in half of the males. After 180 days, proteinuria, glomerular filtration rate (GFR) and blood biochemistry were determined. Kidneys were resected, weighed and subjected to morphologic studies. Following uninephrectomy, male rats developed severe proteinuria: 132.3 +/- 40.9 mg 24 h-1, most of which was accounted for by an albuminuria of 70.9 +/- 19.3 mg 24 h-1. In contrast, protein excretion in female and castrated male rats remained within normal limits: 8.0 +/- 1.8 and 4.2 +/- 0.5 mg 24 h-1, respectively. Mean glomerular volume in male rats was 1.18 +/- 0.08 x 10(6) microns3; much higher than in female rats, 0.84 +/- 0.04 x 10(6) micron3, and castrated male rats, 0.87 +/- 0.03 x 10(6) micron3 (P less than 0.005). On light and electron microscopy, glomeruli of female and castrated male rats were completely normal. In contrast, in four of seven male rats, mild glomerular changes were observed. They consisted mainly of mesangial expansion, electron-dense deposits and collapse of capillary loops. These data suggest that castration confers protection against the development of glomerular hypertrophy and proteinuria in uninephrectomized male rats. Endogenous testosterone may be associated with this development.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Clinical Biochemistry
Renal function
Blood Pressure
Kidney
urologic and male genital diseases
Nephrectomy
Biochemistry
Pathogenesis
Eating
chemistry.chemical_compound
Internal medicine
Testis
medicine
Animals
Testosterone
Proteinuria
business.industry
Body Weight
Rats, Inbred Strains
Hypertrophy
General Medicine
Glomerular Hypertrophy
Rats
Castration
Endocrinology
chemistry
Albuminuria
Female
medicine.symptom
business
Orchiectomy
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 13652362 and 00142972
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Investigation
- Accession number :
- edsair.doi.dedup.....3aa569d98e01f91d19792d8b580fe4ed