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Influence of localization of PSMA-positive oligo-metastases on efficacy of metastasis-directed external-beam radiotherapy—a multicenter retrospective study
- Source :
- European Journal of Nuclear Medicine and Molecular Imaging. 47:1852-1863
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Approximately 40–70% of biochemically persistent or recurrent prostate cancer (PCa) patients after radical prostatectomy (RPE) are oligo-metastatic in 68gallium-prostate-specific membrane antigen positron emission tomography (68Ga-PSMA PET). Those lesions are frequently located outside the prostate bed, and therefore not cured by the current standards of care like external-beam radiotherapy (EBRT) of the prostatic fossa. This retrospective study analyzes the influence of oligo-metastases’ site on outcome after metastasis-directed radiotherapy (MDR). Retrospectively, 359 patients with PET-positive PCa recurrences after RPE were analyzed. Biochemical recurrence-free survival (BRFS) (prostate-specific antigen (PSA)
- Subjects :
- Male
Biochemical recurrence
medicine.medical_specialty
medicine.medical_treatment
Urology
030218 nuclear medicine & medical imaging
Metastasis
Androgen deprivation therapy
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Paraaortic lymph nodes
Positron Emission Tomography Computed Tomography
Humans
Medicine
Radiology, Nuclear Medicine and imaging
External beam radiotherapy
Retrospective Studies
Prostatectomy
business.industry
Prostatic Neoplasms
Androgen Antagonists
General Medicine
Prostate-Specific Antigen
medicine.disease
Radiation therapy
030220 oncology & carcinogenesis
Neoplasm Recurrence, Local
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 16197089 and 16197070
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- European Journal of Nuclear Medicine and Molecular Imaging
- Accession number :
- edsair.doi.dedup.....3ab8c27d86c70a84c9e76c4fff729eb6