Back to Search
Start Over
Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
- Source :
- Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017), Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Increased arterial thickness measured with ultrasound correlates with future cardiovascular events, but conventional ultrasound imaging techniques cannot distinguish between intima, media, or atherosclerotic plaque in the carotid artery. In this work, we evaluated how well vascular elastography can detect intimal changes in a mouse model of carotid remodeling. We ligated the left external and internal branches of the carotid artery of male FVB mice and performed sham operations for 2 weeks. High-resolution ultrasound imaging accurately detected lower blood velocities and low blood volume flow in the carotid arteries after ligation in FVB mice. However, ultrasound could not detect differences in the carotid wall even at 2 weeks post-surgery. The Young’s modulus was measured based on displacements of the carotid artery wall, and Young’s modulus was 2-fold greater in shams at 1 week post ligation, and 3-fold greater 2 weeks after ligation. Finally, the higher Young’s modulus was most associated with higher intimal thickness but not medial or adventitial thickness as measured by histology. In conclusion, we developed a robust ultrasound-based elastography method for early detection of intimal changes in small animals.
- Subjects :
- Male
medicine.medical_specialty
Pathology
Carotid arteries
Science
Early detection
Mice, Inbred Strains
Blood volume
Vascular Remodeling
030204 cardiovascular system & hematology
Conventional ultrasound
Carotid Intima-Media Thickness
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Elastic Modulus
Internal medicine
medicine
Animals
Ligation
Ultrasonography
Multidisciplinary
medicine.diagnostic_test
business.industry
Ultrasound
Models, Cardiovascular
Plaque, Atherosclerotic
Carotid Arteries
Ultrasound imaging
Cardiology
Elasticity Imaging Techniques
Medicine
Elastography
business
Algorithms
Blood Flow Velocity
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....3ab9e737e35d8c55ed288b0ee3b68bd0