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Urocortin-2 in Acute Heart Failure: Role as a Marker of Volume Overload and Pulmonary Hypertension
- Source :
- Current Problems in Cardiology. 47:100860
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Urocortin (Ucn)-2 has shown promising therapeutic effects on heart failure (HF). However, there are still significant knowledge gaps regarding the role and modulation of the endogenous Ucn-2 axis in the cardiovascular system and, specifically, in acute HF. We evaluated Ucn-2 levels in admission serum samples of 80 acute HF patients and assessed their association with clinical, analytical and echocardiographic parameters. Median age was 76.5 years, and 37 patients (46%) were male. Median serum Ucn-2 was 2.3ng/mL. Ucn-2 levels were positively associated with peripheral edemas (P = 0.022), hepatomegaly (P = 0.007) and sodium retention score (ρ = 0.37, P = 0.001) and inversely correlated with inferior vena cava collapse at inspiration (ρ = -0.37, P = 0.001). Additionally, patients with higher Ucn-2 levels had a higher prevalence of right atrial dilation (P = 0.027), right ventricle dilation (P = 0.008), and higher systolic pulmonary artery pressure (ρ = 0.34, P = 0.002). Regarding analytical parameters, Ucn-2 correlated positively with log BNP (r = 0.22, P = 0.055) and inversely with uric acid (r = 0.24, P = 0.029) and total (r = -0.30, P = 0.007) and low-density lipoprotein cholesterol (r = -0.23, P = 0.038). No associations were found between Ucn-2 and age, sex or left heart structure or function. In conclusion, Circulating Ucn-2 was associated with clinical and echocardiographic markers of volume overload and pulmonary hypertension in acute HF patients.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Hypertension, Pulmonary
Volume overload
030204 cardiovascular system & hematology
Inferior vena cava
03 medical and health sciences
0302 clinical medicine
medicine.artery
Internal medicine
otorhinolaryngologic diseases
medicine
Humans
030212 general & internal medicine
Urocortins
Aged
Heart Failure
Urocortin
business.industry
Therapeutic effect
General Medicine
medicine.disease
Pulmonary hypertension
medicine.anatomical_structure
medicine.vein
Echocardiography
Ventricle
Heart failure
Pulmonary artery
Cardiology
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 01462806
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Current Problems in Cardiology
- Accession number :
- edsair.doi.dedup.....3abb30936fff6d6cda0ac45063400100