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Efficacy of tonsillectomy pulse therapy versus multiple-drug therapy for IgA nephropathy
- Source :
- Pediatric Nephrology. 21:1701-1706
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- We evaluated the efficacy of tonsillectomy plus pulse prednisolone, warfarin, and dipyridamole including methylprednisolone pulse (tonsillectomy plus pulse therapy), versus prednisolone, warfarin, and dipyridamole including mizoribine (PWDM) for the treatment diffuse IgA nephropathy (IgAN) in children. The patients were randomly assigned to be treated by tonsillectomy plus pulse therapy for 2 years (Group A, n=16) or PWDM for 2 years (Group B, n=16). The clinical features and pathological findings in both groups were analyzed prospectively. The mean urinary protein excretion after 6 months of treatment in both groups had decreased significantly compared with pre-therapy. The activity index (AI) in both groups was lower at the time of the second biopsy than at the time of the first biopsy. The chronicity index (CI) in Groups A and B did not differ between the first and second biopsy. At the latest follow-up examination none (0%) of the patients in either group had renal insufficiency. None of the patients in Group A, but six patients in Group B experienced an acute exacerbation of IgAN as a result of tonsillitis (P
- Subjects :
- Nephrology
medicine.medical_specialty
Adolescent
Exacerbation
Biopsy
medicine.medical_treatment
Tonsillitis
Kidney
Gastroenterology
Nephropathy
Internal medicine
medicine
Humans
Child
Tonsillectomy
Mizoribine
business.industry
Glomerulonephritis, IGA
medicine.disease
Combined Modality Therapy
Surgery
Proteinuria
Methylprednisolone
Pulse Therapy, Drug
Pediatrics, Perinatology and Child Health
Prednisolone
Drug Therapy, Combination
business
medicine.drug
Subjects
Details
- ISSN :
- 1432198X and 0931041X
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Pediatric Nephrology
- Accession number :
- edsair.doi.dedup.....3ade14bbeb7d2c80376f474372e63bb5
- Full Text :
- https://doi.org/10.1007/s00467-006-0272-6