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Efficacy of tonsillectomy pulse therapy versus multiple-drug therapy for IgA nephropathy

Authors :
Hiroko Sakuma
Masato Isome
Kei Takano
Tomoo Fujiki
Kazuhide Suyama
Yukihiko Kawasaki
Mitsuaki Hosoya
Hitoshi Suzuki
Hideki Suzuki
Source :
Pediatric Nephrology. 21:1701-1706
Publication Year :
2006
Publisher :
Springer Science and Business Media LLC, 2006.

Abstract

We evaluated the efficacy of tonsillectomy plus pulse prednisolone, warfarin, and dipyridamole including methylprednisolone pulse (tonsillectomy plus pulse therapy), versus prednisolone, warfarin, and dipyridamole including mizoribine (PWDM) for the treatment diffuse IgA nephropathy (IgAN) in children. The patients were randomly assigned to be treated by tonsillectomy plus pulse therapy for 2 years (Group A, n=16) or PWDM for 2 years (Group B, n=16). The clinical features and pathological findings in both groups were analyzed prospectively. The mean urinary protein excretion after 6 months of treatment in both groups had decreased significantly compared with pre-therapy. The activity index (AI) in both groups was lower at the time of the second biopsy than at the time of the first biopsy. The chronicity index (CI) in Groups A and B did not differ between the first and second biopsy. At the latest follow-up examination none (0%) of the patients in either group had renal insufficiency. None of the patients in Group A, but six patients in Group B experienced an acute exacerbation of IgAN as a result of tonsillitis (P

Details

ISSN :
1432198X and 0931041X
Volume :
21
Database :
OpenAIRE
Journal :
Pediatric Nephrology
Accession number :
edsair.doi.dedup.....3ade14bbeb7d2c80376f474372e63bb5
Full Text :
https://doi.org/10.1007/s00467-006-0272-6