Back to Search
Start Over
Does progesterone administration in preterm labor influence Treg cells?
- Source :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2016
-
Abstract
- Objectives: The aim of this study was to determine if the actions of progesterone on preterm labor are accomplished through modulation of the percentage of regulatory T-cells (Treg). Methods: The study was a cohort pilot study made in a single center tertiary obstetrical unit with women in preterm labor arrested with tocolytic treatment. Variation of the number and percentage of Treg cells obtained from peripheral blood samples of women with preterm labor were calculated by flow cytometry, before and after progesterone administration. Results: In the paired samples for each patient, there was a significant difference in the Treg cell pool after progesterone treatment, with an increase in both their percentage (48.9 vs. 53; P = 0.07) and absolute number (14.8 vs. 56.5 cells/μL; P = 0.046). Conclusions: This research demonstrated a considerable increase in the Treg cell pool after progesterone treatment. This indicates a possible mechanism for progesterone treatment benefits in preterm labor, potentially increasing its more rational use.
- Subjects :
- Adult
0301 basic medicine
Tocolytic agent
medicine.medical_specialty
Preterm labor
Tocolysis
Pilot Projects
Single Center
T-Lymphocytes, Regulatory
Treg cell
Flow cytometry
Andrology
03 medical and health sciences
Treggs
Obstetric Labor, Premature
Vasotocin
0302 clinical medicine
Pregnancy
medicine
Humans
Progesterone
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
Obstetrics
business.industry
Obstetrics and Gynecology
Flow Cytometry
medicine.disease
Tocolytic Agents
Treatment Outcome
030104 developmental biology
Pediatrics, Perinatology and Child Health
Cohort
Female
Tocolytic treatment
business
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Accession number :
- edsair.doi.dedup.....3b230ab054c42b1d782c3c5f16098887