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Relationship Between the Thymidine Labeling and Ki-67 Proliferative Indices in 126 Breast Cancer Patients
- Source :
- Applied Immunohistochemistry & Molecular Morphology. 10:304-309
- Publication Year :
- 2002
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2002.
-
Abstract
- Proliferative activity has been proposed as a prognostic and predictive marker for breast cancer; Ki-67 is one of the most frequently used markers to assess proliferative activity. In the current study, Ki-67 immunoreactivity was comparatively assessed, even in terms prognostic relevance, with 3H-thymidine labeling index as a reference standard for proliferation in 126 patients with stage I and II breast cancer. There was a significant but weak correlation between Ki-67 values and the 3H-thymidine labeling index (r = 0.19, P = 0.03). Analysis of variance showed that the mean 3H-thymidine labeling index values were not statistically different in terms of pathologic size (T1, T2. T3, T4), number of pathologically positive axillary nodes (neg, pos 1-3, pos > 3), and grading classes (1, 2, 3), but significantly and inversely correlated with estrogen receptor status (P = 0.033) and progesterone receptor status (P = 0.08). The Ki-67 values significantly correlated with N status (P = 0.041), estrogen receptor status (P < 0.001), progesterone receptor status (P < 0.001), and grading (P < 0.001). The median follow-up was 37 months. In terms of prognosis, Ki-67 was associated significantly with overall survival (P = 0.01) and marginally with disease-free survival (P = 0.095). A significant difference in prognosis was found for both disease-free survival (P = 0.024) and overall survival (P = 0.040) when a 3H-thymidine labeling index cut-off of 6.5% was used (P = 0.024). The results suggest that, although both are indicators of proliferative activity, 3H-thymidine labeling index and Ki-67 seem to identify breast cancers with different phenotypes.
- Subjects :
- Oncology
medicine.medical_specialty
Histology
Breast Neoplasms
Tritium
Pathology and Forensic Medicine
Text mining
Breast cancer
Internal medicine
medicine
Humans
Grading (tumors)
Estrogen Receptor Status
Predictive marker
biology
business.industry
Progesterone Receptor Status
Prognosis
medicine.disease
Immunohistochemistry
Medical Laboratory Technology
Ki-67 Antigen
Ki-67
biology.protein
Autoradiography
Female
Analysis of variance
business
Cell Division
Thymidine
Subjects
Details
- ISSN :
- 15412016
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Applied Immunohistochemistry & Molecular Morphology
- Accession number :
- edsair.doi.dedup.....3b348ce145bebaf11942033cc02bcb38