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Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system
Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system
- Source :
- Epilepsy & Behavior. 52:37-41
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Experiencing early-life stress has been considered as a potent risk factor for the development of many of brain disorders, including seizures. Intervening mechanisms through which neonatal maternal separation (MS) alters the seizure susceptibility in adulthood have not been well studied. In the current study, by applying 180 min of MS stress (PND 2-14), we determined the seizure susceptibility and considered the role of the opioid system. Maternal separation increased the seizure threshold, and administration of anticonvulsant/proconvulsant doses of morphine (1 and 30 mg/kg, respectively) reversed the impact of MS. Using tail flick and hot plate tests, we exposed animals to 30 min Restraint stress (RS) and found that MS decreased the pain threshold, suggesting the hyporesponsiveness of the opioid system. These results supported the abnormal seizure activity observed in the MS mice and suggested that abnormalities in the opioid system following MS alter seizure susceptibility in later life.
- Subjects :
- Male
Restraint, Physical
medicine.medical_specialty
medicine.medical_treatment
Mice
Behavioral Neuroscience
Epilepsy
Pregnancy
Seizures
Anxiety, Separation
Internal medicine
Threshold of pain
medicine
Animals
Endorphins
Pain Measurement
Maternal deprivation
Morphine
Seizure threshold
Maternal Deprivation
medicine.disease
Analgesics, Opioid
Anticonvulsant
Endocrinology
Neurology
Anesthesia
Anticonvulsants
Female
Neurology (clinical)
Psychology
Stress, Psychological
medicine.drug
Subjects
Details
- ISSN :
- 15255050
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Epilepsy & Behavior
- Accession number :
- edsair.doi.dedup.....3b3990ed9ebcc9561a21fe77f73a310f
- Full Text :
- https://doi.org/10.1016/j.yebeh.2015.08.025