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Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system

Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system

Authors :
Sakineh Alijanpour
Shahram Ejtemaie Mehr
Ali Mohammadi-Asl
Maryam Rahimi-Balaei
Arya Haj-Mirzaian
Mahsa Hassanipour
Hossein Amini-Khoei
Armin Shirzadian
Ahmad Reza Dehpour
Shayan Amiri
Source :
Epilepsy & Behavior. 52:37-41
Publication Year :
2015
Publisher :
Elsevier BV, 2015.

Abstract

Experiencing early-life stress has been considered as a potent risk factor for the development of many of brain disorders, including seizures. Intervening mechanisms through which neonatal maternal separation (MS) alters the seizure susceptibility in adulthood have not been well studied. In the current study, by applying 180 min of MS stress (PND 2-14), we determined the seizure susceptibility and considered the role of the opioid system. Maternal separation increased the seizure threshold, and administration of anticonvulsant/proconvulsant doses of morphine (1 and 30 mg/kg, respectively) reversed the impact of MS. Using tail flick and hot plate tests, we exposed animals to 30 min Restraint stress (RS) and found that MS decreased the pain threshold, suggesting the hyporesponsiveness of the opioid system. These results supported the abnormal seizure activity observed in the MS mice and suggested that abnormalities in the opioid system following MS alter seizure susceptibility in later life.

Details

ISSN :
15255050
Volume :
52
Database :
OpenAIRE
Journal :
Epilepsy & Behavior
Accession number :
edsair.doi.dedup.....3b3990ed9ebcc9561a21fe77f73a310f
Full Text :
https://doi.org/10.1016/j.yebeh.2015.08.025