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Cigarette Experimentation in Mexican Origin Youth: Psychosocial and Genetic Determinants

Cigarette Experimentation in Mexican Origin Youth: Psychosocial and Genetic Determinants

Authors :
Anna V. Wilkinson
Xia Pu
Jian Wang
Sanjay Shete
Anthony M. D'Amelio
Margaret R. Spitz
Robert Yu
Xifeng Wu
Carol J. Etzel
Alexander V. Prokhorov
Qiong Dong
Melissa L. Bondy
Source :
Cancer Epidemiology, Biomarkers & Prevention. 21:228-238
Publication Year :
2012
Publisher :
American Association for Cancer Research (AACR), 2012.

Abstract

Background: Established psychosocial risk factors increase the risk for experimentation among Mexican origin youth. Now, we comprehensively investigate the added contribution of select polymorphisms in candidate genetic pathways associated with sensation seeking, risk taking, and smoking phenotypes to predict experimentation. Methods: Participants (N = 1,118 Mexican origin youth) recruited from a large population-based cohort study in Houston, TX, provided prospective data on cigarette experimentation over 3 years. Psychosocial data were elicited twice—baseline and final follow-up. Participants were genotyped for 672 functional and tagging variants in the dopamine, serotonin, and opioid pathways. Results: After adjusting for gender and age, with a Bayesian False Discovery Probability set at 0.8 and prior probability of 0.05, six gene variants were significantly associated with risk of experimentation. After controlling for established risk factors, multivariable analyses revealed that participants with six or more risk alleles were 2.25 [95% confidence interval (CI), 1.62–3.13] times more likely to have experimented since baseline than participants with five or fewer. Among committed never-smokers (N = 872), three genes (OPRM1, SNAP25, HTR1B) were associated with experimentation as were all psychosocial factors. Among susceptible youth (N = 246), older age at baseline, living with a smoker, and three different genes (HTR2A, DRD2, SLC6A3) predicted experimentation. Conclusions: Our findings, which have implications for development of culturally specific interventions, need to be validated in other ethnic groups. Impact: These results suggest that variations in select genes interact with a cognitive predisposition toward smoking. In susceptible adolescents, the impact of the genetic variants appears to be larger than committed never-smokers. Cancer Epidemiol Biomarkers Prev; 21(1); 228–38. ©2011 AACR.

Details

ISSN :
15387755 and 10559965
Volume :
21
Database :
OpenAIRE
Journal :
Cancer Epidemiology, Biomarkers & Prevention
Accession number :
edsair.doi.dedup.....3b4f8cdc7cbdc20d6445eb7f3adb68b7
Full Text :
https://doi.org/10.1158/1055-9965.epi-11-0456