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Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients
- Source :
- Current Medical Science
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Summary The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease. Understanding the dysregulated human immune responses in the fatal subjects is critical for management of COVID-19 patients and the pandemic. In this study, we examined the immune cell compositions in the lung tissues and hilar lymph nodes using immunohistochemistry on 6 deceased COVID-19 patients and 4 focal organizing pneumonia (FOP) patients who underwent lung surgery and served as controls. We found a dominant presence of macrophages and a general deficiency of T cells and B cells in the lung tissues from deceased COVID-19 patients. In contrast to the FOP patients, Tfh cells and germinal center formation were largely absent in the draining hilar lymph nodes in the deceased COVID-19 patients. This was correlated with reduced IgM and IgG levels compared to convalescent COVID-19 patients. In summary, our data highlight a defect of germinal center structure in deceased COVID-19 patients leading to an impaired humoral immunity. Understanding the mechanisms of this deficiency will be one of the key points for the management of this epidemic.
- Subjects :
- Male
China
Pneumonia, Viral
Disease
Adaptive Immunity
Biochemistry
Article
Betacoronavirus
Fatal Outcome
Immune system
Lymphopenia
medicine
Genetics
Humans
Pandemics
Aged
Aged, 80 and over
Lung
SARS-CoV-2
business.industry
Macrophages
Case-control study
COVID-19
Germinal center
T-Lymphocytes, Helper-Inducer
Middle Aged
Germinal Center
Acquired immune system
immune responses
medicine.anatomical_structure
Case-Control Studies
Humoral immunity
Immunology
T follicular helper cells
Immunohistochemistry
Female
Coronavirus Infections
business
Subjects
Details
- Language :
- English
- ISSN :
- 2523899X and 20965230
- Database :
- OpenAIRE
- Journal :
- Current Medical Science
- Accession number :
- edsair.doi.dedup.....3b6903dd3da7ec6d026ed94a5402e4a9
- Full Text :
- https://doi.org/10.1007/s11596-020-2225-x