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Socio-Economic Variations Determine the Clinical Presentation, Aetiology and Outcome of Infective Endocarditis: a Prospective Cohort Study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry
Authors :
Sengupta, Shantanu P Prendergast, Bernard Laroche, Cécile Furnaz, Shumaila Ronderos, Ricardo Almaghraby, Abdallah Asch, Federico M Blechova, Kamila Zaky, Hosam Strahilevitz, Jacob Dworakowski, Rafal Miyasaka, Yoko Sebag, Igal Izumi, Chisato Axler, Olivier Jamiel, Abdulrahman Philip, Mary Campos Vieira, Marcelo Luiz Lancellotti, Patrizio Habib, Gilbert P Gale, C Beleslin, B Budaj, A Chioncel, O Dagres, N Danchin, N Emberson, J Erlinge, D Glikson, M Gray, A Kayikcioglu, M P Maggioni, A K Nagy, V Nedoshivin, A A-S, Petronio Roos-Hesselink, J Wallentin, L Zeymer, U Habib, G Lancellotti, P Cosyns, B Donal, E Erba, P Iung, B A Popescu, B Prendergast, B Tornos, P Andarala, M Berle, C Brunel-Lebecq, A Fiorucci, E Laroche, C Missiamenou, V Taylor, C N Ali Tatar-Chentir, N Al-Mallah, M M Astrom Aneq Athanassopoulos, G P Badano, L Benyoussef, S E Calderon Aranda M Cardim, N K-L, Chan Cruz, I Edvardsen, T Goliasch, G Hagendorff, A Hristova, K Kamp, O D-H, Kang Kong, W Matskeplishvili, S Meshaal, M Mirocevic, M N Neskovic, A Pazdernik, M Plonska-Gosciniak, E Raissouni, M Ronderos, R E Sade, L Sadeghpour, A Sambola, A Sengupta, S Separovic-Hanzevacki, J Takeuchi, M Tucay, E C Tude Rodrigues, A Varga, A Vaskelyte, J Yamagata, K Yiangou, K Zaky, H Granada, I Mahia, M Ressi, S Nacinovich, F Iribarren, A P Fernandez Oses Avegliano, G Filipini, E Obregon, R Bangher, M Dho, J Cartasegna, L L Plastino, M Novas, V Shigel, C Reyes, G M De Santos Gastaldello, N M Granillo Fernandez Potito, M Streitenberger, G Velazco, P H Casabé, J Cortes, C Guevara, E Salmo, F Seijo, M Weidinger, F Heger, M Brooks, R Stöllberger, C C-Y, Ho Perschy, L Puskas, L Binder, C Rosenhek, R Schneider, M M-P, Winter Hoffer, E Melissopoulou, M Lecoq, E Legrand, D Jacquet, S Massoz, M Pierard, L Marchetta, S Dulgheru, R D Emal, C Oury, C Droogmans, S Kerkhove, D Plein, D Soens, L Weytjens, C Motoc, A Roosens, B Lemoine, I Rodrigus, I Paelinck, B Amsel, B Unger, P Konopnicki, D Beauloye, C Pasquet, A L Vanoverschelde, J Pierard, S Vancraeynest, D Sinnaeve, F L Andrade, J Staszko, K R Dos Santos Monteiro H Miglioranza, M L Shuha, D Alcantara, M Cravo, V Fazzio, L Felix, A Iso, M Musa, C P Siciliano, A F Villaca Filho Rodrigues, A Vilela, F Braga, J Silva, R Rodrigues, D Silva, L Morhy, S Fischer, C Vieira, M Afonso, T Abreu, J N Falcao, S A Moises, V Gouvea, A J Mancuso, F C Souza, A Y Silva, C João, G S Abboud, C R Bellio de Mattos Barretto Ramos, A Arnoni, R E Assef, J J Della Togna, D D Le Bihan Miglioli, L P Romero Oliveira, A R Tadeu Magro Kroll Cortez, D L Gelape, C M D, C Peirira Nunes C De Abreu Ferrari, T Hay, K V, Le Page, M Poulin, F Sauve, C Serri, K Mercure, C Beaudoin, J Pibarot, P A Sebag, I G Rudski, L Ricafort, G Barsic, B Krajinovic, V Vargovic, M Lovric, D Reskovic-Luksic, V Vincelj, J S Jaksic Jurinjak Yiannikourides, V Ioannides, M Pofaides, C Masoura, V Pudich, J Linhart, A Siranec, M Marek, J Blechova, K Kamenik, M Pelouch, R Coufal, Z Mikulica, M Griva, M Jancova, E Mikulcova, M Taborsky, M Precek, J Jecmenova, M Latal, J Widimsky, J Butta, T Machacek, S Vancata, R Spinar, J Holicka, M F Pow Chon Long Anzules, N A Bajana Carpio Largacha, G Penaherrera, E Moreira, D Mahfouz, E Elsafty, E Soliman, A Zayed, Y Aboulenein, J Abdel-Hay, M Almaghraby, A Abdelnaby, M Ahmed, M Hammad, B Saleh, Y Zahran, H Elgebaly, O Saad, A Ali, M Zeid, A R El Sharkawy A Al Kholy Doss, R Osama, D Rizk, H Elmogy, A Mishriky, M Assayag, P S El Hatimi Hubert, S J-P, Casalta Gouriet, F Arregle, F Cammilleri, S Tessonnier, L Riberi, A Botelho-Nevers, E Gagneux-Brunon, A Pierrard, R Tulane, C Campisi, S J-F, Fuzellier Detoc, M Mehalla, T Boutoille, D S Lecompte, A Lefebvre, M Pattier, S O Al Habash Asseray-Madani, N Biron, C Brochard, J Caillon, J Cueff, C T Le Tourneau Lecomte, R M Magali Michel, M Orain, J Delarue, S M Le Bras J-F, Faucher Aboyans, V Beeharry, A Durox, H Lacoste, M Magne, J Mohty, D David, A Pradel, V Sierra, V Neykova, A Bettayeb, B Elkentaoui, S Tzvetkov, B Landry, G Strady, C Ainine, K Baumard, S Brasselet, C Tassigny, C Valente-Pires, V Lefranc, M Hoen, B Lefevre, B Curlier, E Callier, C Fourcade, N Jobic, Y Ansard, S R Le Berre F Le Ven M-C, Pouliquen Prat, G P Le Roux Bouchart, F Savoure, A Alarcon, C Chapuzet, C Gueit, I Tribouilloy, C Bohbot, Y Peugnet, F Gun, M Duval, X Lescure, X Ilic-Habensus, E Sadoul, N Selton-Suty, C Alla, F Goehringer, F Huttin, O Chevalier, E Garcia, R V Le Marcis Tattevin, P Flecher, E Revest, M Chirouze, C Bouiller, K Hustache-Mathieu, L Klopfenstein, T Moreau, J Fournier, D A-S, Brunel Lim, P Oliver, L Ternacle, J Moussafeur, A Chavanet, P Piroth, L Salmon-Rousseau, A Buisson, M Mahy, S Martins, C Gohier, S Axler, O Baumann, F Lebras, S Piper, C Guckel, D Börgermann, J Horstkotte, D Winkelmann, E Brockmeier, B Grey, D Nickenig, G Schueler, R Öztürk, C Stöhr, E Hamm, C Walther, T Brandt, R A-C, Frühauf T Hartung, C Hellner, C Wild, C Becker, M Hamada, S Kaestner, W Stangl, K Knebel, F Baldenhofer, G Brecht, A Dreger, H Isner, C Pfafflin, F Stegemann, M Zahn, R Fraiture, B Kilkowski, C A-K, Karcher Klinger, S Tolksdorf, H Tousoulis, D Aggeli, C Sideris, S Venieri, E Sarri, G Tsiapras, D Armenis, I Koutsiari, A Floros, G Grassos, C Dragasis, S Rallidis, L Varlamos, C Michalis, L Naka, K Bechlioulis, A Kotsia, A Lakkas, L Pappas, K Papadopoulos, C Kiokas, S Lioni, A Misailidou, S Barbetseas, J Bonou, M Kapelios, C Tomprou, I Zerva, K Manolis, A Hamodraka, E Athanasiou, D Haralambidis, G Samaras, H Poulimenos, L Nagy, A Bartykowszki, A Gara, E Mungulmare, K Kasliwal, R Bansal, M Ranjan, S Bhan, A Kyavar, M Maleki, M F Noohi Bezanjani Alizadehasl, A Boudagh, S Ghavidel, A Moradnejad, P R Pasha, H Ghadrdoost, B Gilon, D Strahilevitz, J Wanounou, M Israel, S D'Agostino, C Colonna, P L De Michele Fumarola, F Stante, M Marchionni, N Scheggi, V Alterini, B S Del Pace Stefano, P Sparano, C Ruozi, N Tenaglia, R Muraru, D Limbruno, U Cresti, A Baratta, P Solari, M Giannattasio, C Moreo, A B De Chiara B Lopez Montero Musca, F A Orcese, C Panzeri, F Spano, F F Russo, C Alfieri, O M De Bonis Chiappetta, S B Del Forno Ripa, M Scarpellini, P C Tassan Din Castiglioni, B Pasciuta, R Carletti, S Ferrara, D Guffanti, M Iaci, G Lapenna, E Nisi, T Oltolini, C Busnardo, E Pajoro, U Agricola, E Meneghin, R Schiavi, D Piscione, F Citro, R M Benvenga, R Greco, L Soriente, L Radano, I Prota, C Bellino, M D Di Vece Santini, F Salsano, A M Olivieri, G Turrini, F Messora, R Tondi, S Olaru, A Agnoletto, V Grassi, L Leonardi, C Sansoni, S S Del Ponte M Actis Dato, G A De Martino Ohte, N Kikuchi, S Wakami, K Aonuma, K Seo, Y Ishizu, T Machino-Ohtsuka, T Yamamoto, M Iida, N Nakajima, H Nakagawa, Y Izumi, C Amano, M Miyake, M Takahashi, K Shiojima, I Miyasaka, Y Maeba, H Suwa, Y Taniguchi, N Tsujimoto, S Kitai, T Ota, M Yuda, S Sasaki, S Hagiwara, N Yamazaki, K Ashihara, K Arai, K Saitou, C Saitou, S Suzuki, G Shibata, Y Watanabe, N Nishino, S Ashikaga, K Kuriyama, N Mahara, K Okubo, T Fujimaki, H Shitan, H Yamamoto, H Abe, K Terada, M Takanashi, S Sata, M Yamada, H Kusunose, K Saijo, Y Seno, H Yuichiro, O Onishi, T Sera, F Nakatani, S Mizuno, H Sengoku, K W Park, S K Eun Kyoung L Ga Yeon J-W, Hwang Jin-Oh, C S-J, Park Sang-Chol, L Sung-A, C Y Jang, S Heo, R Lee, S J-M, Song Jung, E Plisiene, J Dambrauskaite, A Gruodyte, G Jonkaitiene, R Mizariene, V Atkocaityte, J Zvirblyte, R Sow, R Codreanu, A Staub, T Michaux, C E C, L De la Vega Jacobs-Orazi, L C Mallia Azzopardi G Xuereb, R Piscopo, T Farrugia, J Fenech, M Pllaha, E Vella, C Borg, D Casha, R Grib, L Raevschi, E Grejdieru, A Kravcenco, D Prisacari, E Samohvalov, E Samohvalov, S Sceglova, N Panfile, E Cardaniuc, L Corcea, V Feodorovici, A Gaina, V Girbu, L Jimbei, P Balan, G Cardaniuc, I Benesco, I Marian, V Sumarga, N Bozovic, B Bulatovic, N Lakovic, P Music, L Budde, R Wahadat, A Gamela, T Meijers, T P Van Melle, J M Deursen, V J Crijns, H C Bekkers, S C Cheriex, E Gilbers, M L Kietselaer, B Knackstedt, C Lorusso, R Schalla, S A Streukens, S Chamuleau, S M-J, Cramer Teske, A T Van der Spoel Wind, A Lokhorst, J Liesbek, O H Van Heusden Tanis, W I Van der Bilt Vriend, J H De Lange-van Bruggen Karijodikoro, E Riezebos, R E van Dongen Schoep, J Stolk, V T Offstad, J O Beitnes, J Helle-Valle, T Skulstad, H Skardal, R Qamar, N Furnaz, S Ahmed, B H Butt, M F Khanzada, M Saghir, T Wahid, A Hryniewiecki, T Szymanski, P Marzec, K Misztal-Ogonowska, M Kosmala, W Przewlocka-Kosmala, M Rojek, A Woznicka, K Zachwyc, J Lisowska, A Kaminska, M D Kasprzak, J Kowalczyk, E F Strzecka, D Wejner-Mik, P Trabulo, M Freitas, P Ranchordas, S Rodrigues, G Pinto, P Queiros, C Azevedo, J Marques, L Seabra, D Branco, L Cruz, M Galrinho, A Moreira, R Rio, P T Timoteo, A Selas, M Carmelo, V B Duque Neves Pereira, H Guerra, A Marques, A Pintassilgo, I C Tomescu, M N-M, Trofenciuc Andor, M Bordejevic, A S Branea, H Caruntu, F A Velcean, L Mavrea, A F Onel, M Parvanescu, T Pop, D L Pop-Moldovan, A I Puticiu, M Cirin, L M Citu, I A Cotoraci, C Darabantiu, D Farcas, R Marincu, I Ionac, A Cozma, D Mornos, C Goanta, F Popescu, I Beyer, R Mada, R Rancea, R Tomoaia, R Rosianu, H Stanescu, C Kobalava, Z Karaulova, J Kotova, E Milto, A Pisaryuk, A Povalyaev, N Sorokina, M Alrahimi, J Elshiekh, A Jamiel, A Ahmed, A Attia, N Putnikovic, B Dimic, A Ivanovic, B Matic, S Trifunovic, D Petrovic, J Kosevic, D Stojanovic, I Petrovic, I Dabic, P Milojevic, P Srdanovic, I Susak, S Velicki, L Vulin, A Kovacevic, M Redzek, A Stefanovic, M C Yeo, T W K, F Kong K Poh, K Vilacosta, I Ferrera, C Olmos, C M Abd El Nasser F Calvo Iglesias Blanco-Gonzalez, E M Bravo Amaro Lopez-Rodriguez, E J Lugo Adan N Germinas, A Pazos-Lopez, P M Pereira Loureiro T Perez, M Raposeiras-Roubin, S S Rasheed Yas M-M, Suarez-Varela F Vasallo Vidal Garcia-Dorado, D Fernandez-Hidalgo, N Gonzalez-Alujas, T Lozano, J Maisterra, O Pizzi, N Rios, R Bayes-Genis, A L Pedro Botet Vallejo, N Llibre, C Mateu, L Nunez, R Quesada, D Berastegui, E D Bosch Portell J Aboal Vinas X Albert Bertran R Brugada Tarradellas P Loma-Osorio Ricon C Tiron de Llano A Arnau, M Bel, A Blanes, M Osa, A Anguita, M Carrasco, F C Castillo, J L Zamorano, J L Moya Mur, J Alvaro, M Fernandez-Golfin, C M Monteagudo, J E Navas Elorza C Farinas Alvarez, M J Aguero Balbin Zarauza, J F Gutierrez-Diez, J Arminanzas, C F Arnaiz de Las Revillas A Arnaiz Garcia M Cobo Belaustegui M Fernandez Sampedro M Gutierrez Cuadra L Garcia Cuello C Gonzalez Rico Rodriguez-Alvarez, R Goikoetxea, J Montejo, M M Miro, J Almela, M Ambrosioni, J Moreno, A Quintana, E Sandoval, E Tellez, A M Tolosana, J Vidal, B Falces, C Fuster, D Garcia-de-la-Maria, C Hernandez-Meneses, M Llopis, J Marco, F Ruiz-Zamora, I A Bardaji Ruiz E Sanz Girgas Garcia-Pardo, G M Guillen Marzo A Rodriguez Oviedo A Villares Jimenez Abid, L Hammami, R Kammoun, S S Mourali, M F Mghaieth Zghal M Ben Hlima Boudiche, S Ouali, S Zakhama, L Antit, S Slama, I Gulel, O Sahin, M Karacaglar, E Kucukoglu, S Cetinarslan, O S Yasar, U Canpolat, U Mutlu, B Atas, H Dervishova, R Ileri, C Alhashmi, J Tahir, J Zarger, P Baslib, F Woldman, S Menezes, L Primus, C Uppal, R Bvekerwa, I Chandrasekaran, B Kopanska, A Chambers, J Hancock, J Klein, J Rajani, R P Ursi, M Cannata, S Dworakowski, R Fife, A Breeze, J Browne-Morgan, M Gunning, M Streather, S M Asch, F Zemedkun, M Alyavi, B Uzokov, J Microbes évolution phylogénie et infections (MEPHI) Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) Département de Cardiologie [Hôpital de la Timone - APHM] Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE) CHU Pontchaillou [Rennes] ARN régulateurs bactériens et médecine (BRM) Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) 2011–21, Abbott Vascular 2009–18, Amgen 2016–19, Edwards 2014–16, Gedeon Richter 2009–12, Menarini Group 2011–14, MSD 2014–20, Novartis Pharma 2014–16, ResMed Foundation 2009–11, Sanofi 2009–21, Servier 2019–22, Vifor Pharma 2014–21, AstraZeneca 2009–18, Bayer AG 2009–19, Boehringer Ingelheim 2009–12, Boston Scientific Bristol Myers Squibb 2011–19, Pfizer Alliance 2011–20, Daiichi Sankyo Company 2014–17, Eli Lilly and Company Sengupta, S Prendergast, B Laroche, C Furnaz, S Ronderos, R Almaghraby, A Asch, F Blechova, K Zaky, H Strahilevitz, J Dworakowski, R Miyasaka, Y Sebag, I Izumi, C Axler, O Jamiel, A Philip, M Vieira, M Lancellotti, P Habib, G Gale, C Beleslin, B Budaj, A Chioncel, O Dagres, N Danchin, N Emberson, J Erlinge, D Glikson, M Gray, A Kayikcioglu, M Maggioni, A Nagy, V Nedoshivin, A Petronio, A Roos-Hesselink, J Wallentin, L Zeymer, U Cosyns, B Donal, E Erba, P Iung, B Popescu, B Tornos, P Andarala, M Berle, C Brunel-Lebecq, A Fiorucci, E Missiamenou, V Taylor, C Ali Tatar-Chentir, N Al-Mallah, M Astrom Aneq, M Athanassopoulos, G Badano, L Benyoussef, S Calderon Aranda, E Cardim, N Chan, K Cruz, I Edvardsen, T Goliasch, G Hagendorff, A Hristova, K Kamp, O Kang, D Kong, W Matskeplishvili, S Meshaal, M Mirocevic, M Neskovic, A Pazdernik, M Plonska-Gosciniak, E Raissouni, M Sade, L Sadeghpour, A Sambola, A Separovic-Hanzevacki, J Takeuchi, M Tucay, E Tude Rodrigues, A Varga, A Vaskelyte, J Yamagata, K Yiangou, K Granada, I Mahia, M Ressi, S Na-Cinovich, F Iribarren, A Fernandez Oses, P Avegliano, G Filipini, E Obregon, R Bangher, M Dho, J Cartasegna, L Plastino, M Novas, V Shigel, C Reyes, G De Santos, M Gastaldello, N Granillo Fernandez, M Potito, M Streit-Enberger, G Velazco, P Casabe, J Cortes, C Guevara, E Salmo, F Seijo, M Weidinger, F Heger, M Brooks, R Stollberger, C Ho, C Perschy, L Puskas, L Binder, C Rosenhek, R Schneider, M Winter, M Hoffer, E Melis-Sopoulou, M Lecoq, E Legrand, D Jacquet, S Massoz, M Pierard, L Marchetta, S Dulgheru, R D'Emal, C Oury, C Droog-Mans, S Kerkhove, D Plein, D Soens, L Weytjens, C Motoc, A Roosens, B Lemoine, I Rodrigus, I Paelinck, B Am-Sel, B Unger, P Konopnicki, D Beauloye, C Pasquet, A Vanoverschelde, J Pierard, S Vancraeynest, D Sinnaeve, F Andrade, J Staszko, K Dos Santos Monteiro, R Miglioranza, M Shuha, D Alcantara, M Cravo, V Fazzio, L Felix, A Iso, M Musa, C Siciliano, A Villaca Filho, F Rodrigues, A Vilela, F Braga, J Silva, R Rodrigues, D Silva, L Morhy, S Fischer, C Afonso, T Abreu, J Falcao, S Moises, V Gou-Vea, A Mancuso, F Souza, A Silva, C Joao, G Abboud, C Bellio de Mattos Barretto, R Ramos, A Arnoni, R Assef, J Della Togna, D Le Bihan, D Miglioli, L Romero Oliveira, A Tadeu Magro Kroll, R Cortez, D Gelape, C Peirira Nunes, M De Abreu Ferrari, T Hay, K Le, V Page, M Poulin, F Sauve, C Serri, K Mercure, C Beaudoin, J Pibarot, P Rudski, L Ricafort, G Barsic, B Krajinovic, V Vargovic, M Lovric, D Reskovic-Luksic, V Vincelj, J Jaksic Jurinjak, S Yiannikourides, V Ioannides, M Pofaides, C Masoura, V Pudich, J Linhart, A Siranec, M Marek, J Kamenik, M Pelouch, R Coufal, Z Mikulica, M Griva, M Jancova, E Mikulcova, M Taborsky, M Precek, J Jecmenova, M Latal, J Widimsky, J Butta, T Machacek, S Vancata, R Spinar, J Holicka, M Pow Chon Long, F Anzules, N Bajana Carpio, A Largacha, G Penaherrera, E Moreira, D Mahfouz, E Elsafty, E Soliman, A Zayed, Y Aboulenein, J Abdel-Hay, M Abdelnaby, M Ahmed, M Hammad, B Saleh, Y Zahran, H El-Gebaly, O Saad, A Ali, M Zeid, A El Sharkawy, R Al Kholy, A Doss, R Osama, D Rizk, H Elmogy, A Mishriky, M Assayag, P El Hatimi, S Hubert, S Casalta, J Gouriet, F Arregle, F Cammilleri, S Tessonnier, L Riberi, A Botelho-Nevers, E Gagneux-Brunon, A Pierrard, R Tulane, C Campisi, S Fuzellier, J Detoc, M Mehalla, T Boutoille, D Lecompte, A Lefebvre, M Pattier, S Al Habash, O Asseray-Madani, N Biron, C Brochard, J Caillon, J Cueff, C Le Tourneau, T Lecomte, R Magali Michel, M Orain, J Delarue, S Le Bras, M Faucher, J Aboyans, V Bee-Harry, A Durox, H Lacoste, M Magne, J Mohty, D David, A Pradel, V Sierra, V Neykova, A Bettayeb, B Elkentaoui, S Tzvetkov, B Landry, G Strady, C Ainine, K Baumard, S Brasselet, C Tassigny, C Valente-Pires, V Lefranc, M Hoen, B Lefevre, B Curlier, E Callier, C Fourcade, N Jobic, Y Ansard, S Le Berre, R Le Ven, F Pouliquen, M Prat, G Le Roux, P Bouchart, F Savoure, A Alarcon, C Chapuzet, C Gueit, I Tribouilloy, C Bohbot, Y Peugnet, F Gun, M Duval, X Lescure, X Ilic-Habensus, E Sadoul, N Selton-Suty, C Alla, F Goehringer, F Huttin, O Chevalier, E Garcia, R Le Marcis, V Tattevin, P Flecher, E Revest, M Chirouze, C Bouiller, K Hustache-Mathieu, L Klopfenstein, T Moreau, J Fournier, D Brunel, A Lim, P Oliver, L Ternacle, J Moussafeur, A Chavanet, P Piroth, L Salmon-Rousseau, A Buisson, M Mahy, S Martins, C Go-Hier, S Baumann, F Lebras, S Piper, C Guckel, D Borgermann, J Horstkotte, D Winkelmann, E Brockmeier, B Grey, D Nick-Enig, G Schueler, R Ozturk, C Stohr, E Hamm, C Walther, T Brandt, R Fruhauf, A Hartung, C Hellner, C Wild, 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Alhashmi, J Tahir, J Zarger, P Baslib, F Woldman, S Menezes, L Primus, C Uppal, R Bvekerwa, I Chandrasekaran, B Kopanska, A Chambers, J Hancock, J Klein, J Rajani, R Ursi, M Cannata, S Fife, A Breeze, J Browne-Morgan, M Gunning, M Streather, S Zemedkun, M Alyavi, B Uzokov, J
Source :
European Heart Journal. Quality of Care and Clinical Outcomes, European Heart Journal. Quality of Care and Clinical Outcomes, 2022, 9 (1), pp.85-96. ⟨10.1093/ehjqcco/qcac012⟩
Publication Year :
2022
Publisher :
HAL CCSD, 2022.
Abstract
Aims Infective endocarditis (IE) is a life-threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socioeconomic factors might influence its epidemiology, clinical presentation, investigation and management, and outcome, in a large international multicentre registry. Methods and results The EurObservational Programme (EORP) of the European Society of Cardiology EURO-ENDO (European Infective Endocarditis) registry comprises a prospective cohort of 3113 adult patients admitted for IE in 156 hospitals in 40 countries between January 2016 and March 2018. Patients were separated in three groups, according to World Bank economic stratification [group 1: high income (75.6%); group 2: upper-middle income (15.4%); group 3: lower-middle income (9.1%)]. Group 3 patients were younger [median age (interquartile range, IQR): group 1, 66 (53–75) years; group 2, 57 (41–68) years; group 3, 33 (26–43) years; P < 0.001] with a higher frequency of smokers, intravenous drug use, and human immunodeficiency virus infection (all P < 0.001) and presented later [median (IQR) days since symptom onset: group 1, 12 (3–35); group 2, 19 (6–54); group 3, 31 (12–62); P < 0.001] with a higher likelihood of developing congestive heart failure (13.6%, 11.1%, and 22.6%, respectively; P < 0.001) and persistent fever (9.8%, 14.2%, and 27.9%, respectively; P < 0.001). Among 2157 (69.3%) patients with theoretical indication for cardiac surgery, surgery was performed less frequently in group 3 patients (75.5%, 76.8%, and 51.3%, respectively; P < 0.001), who also demonstrated the highest mortality (15.0%, 23.0%, and 23.7%, respectively; P < 0.001). Conclusion Socioeconomic factors influence the clinical profile of patients presenting with IE across the world. Despite younger age, patients from the poorest countries presented with more frequent complications and higher mortality associated with delayed diagnosis and lower use of surgery.
Details
Language :
English
ISSN :
20585225 and 20581742
Database :
OpenAIRE
Journal :
European Heart Journal. Quality of Care and Clinical Outcomes, European Heart Journal. Quality of Care and Clinical Outcomes, 2022, 9 (1), pp.85-96. ⟨10.1093/ehjqcco/qcac012⟩
Accession number :
edsair.doi.dedup.....3b6d944f0573e11414f141f8ddce8da3