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Evaluation of the Biological Behavior of a Gold Nanocore-Encapsulated Human Serum Albumin Nanoparticle (Au@HSANP) in a CT-26 Tumor/Ascites Mouse Model after Intravenous/Intraperitoneal Administration
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 20, Iss 1, p 217 (2019), Volume 20, Issue 1
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- Colorectal cancer is one of the major causes of cancer-related death in Taiwan and worldwide. Patients with peritoneal metastasis from colorectal cancer have reduced overall survival and poor prognosis. Hybrid protein-inorganic nanoparticle systems have displayed multifunctional applications in solid cancer theranostics. In this study, a gold nanocore-encapsulated human serum albumin nanoparticle (Au@HSANP), which is a hybrid protein-inorganic nanoparticle, and its radioactive surrogate 111In-labeled Au@HSANP (111In-Au@HSANP), were developed and their biological behaviors were investigated in a tumor/ascites mouse model. 111In-Au@HSANP was injected either intravenously (iv) or intraperitoneally (ip) in CT-26 tumor/ascites-bearing mice. After ip injection, a remarkable and sustained radioactivity retention in the abdomen was noticed, based on microSPECT images. After iv injection, however, most of the radioactivity was accumulated in the mononuclear phagocyte system. The results of biodistribution indicated that ip administration was significantly more effective in increasing intraperitoneal concentration and tumor accumulation than iv administration. The ratios of area under the curve (AUC) of the ascites and tumors in the ip-injected group to those in the iv-injected group was 93 and 20, respectively. This study demonstrated that the ip injection route would be a better approach than iv injections for applying gold-albumin nanoparticle in peritoneal metastasis treatment.
- Subjects :
- Colorectal cancer
medicine.medical_treatment
Hybrid protein-inorganic nanoparticle
Nanoparticle
02 engineering and technology
Pharmacology
lcsh:Chemistry
Mice
0302 clinical medicine
Ascites
intravenous injection
Tissue Distribution
lcsh:QH301-705.5
Spectroscopy
Chemistry
Indium Radioisotopes
Area under the curve
General Medicine
Mononuclear phagocyte system
021001 nanoscience & nanotechnology
Human serum albumin
Computer Science Applications
030220 oncology & carcinogenesis
Area Under Curve
Injections, Intravenous
Administration, Intravenous
medicine.symptom
0210 nano-technology
Injections, Intraperitoneal
medicine.drug
Biodistribution
Cell Survival
Intraperitoneal injection
Serum Albumin, Human
intraperitoneal injection
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
tumor/ascites animal model
medicine
Animals
Physical and Theoretical Chemistry
Particle Size
Molecular Biology
Tomography, Emission-Computed, Single-Photon
Organic Chemistry
medicine.disease
Dynamic Light Scattering
Disease Models, Animal
lcsh:Biology (General)
lcsh:QD1-999
Nanoparticles
Gold
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....3b71a0693bfd51e9e1af879ec4e6a8b6