Back to Search
Start Over
Oxygenation of adipose tissue: A human perspective
- Source :
- Acta Physiologica (Oxford, England)
- Publication Year :
- 2019
-
Abstract
- Obesity is a complex disorder of excessive adiposity, and is associated with adverse health effects such as cardiometabolic complications, which are to a large extent attributable to dysfunctional white adipose tissue. Adipose tissue dysfunction is characterized by adipocyte hypertrophy, impaired adipokine secretion, a chronic low‐grade inflammatory status, hormonal resistance and altered metabolic responses, together contributing to insulin resistance and related chronic diseases. Adipose tissue hypoxia, defined as a relative oxygen deficit, in obesity has been proposed as a potential contributor to adipose tissue dysfunction, but studies in humans have yielded conflicting results. Here, we will review the role of adipose tissue oxygenation in the pathophysiology of obesity‐related complications, with a specific focus on human studies. We will provide an overview of the determinants of adipose tissue oxygenation, as well as the role of adipose tissue oxygenation in glucose homeostasis, lipid metabolism and inflammation. Finally, we will discuss the putative effects of physiological and experimental hypoxia on adipose tissue biology and whole‐body metabolism in humans. We conclude that several lines of evidence suggest that alteration of adipose tissue oxygenation may impact metabolic homeostasis, thereby providing a novel strategy to combat chronic metabolic diseases in obese humans.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
obesity
Physiology
WEIGHT-LOSS
Adipose tissue
Adipokine
Inflammation
White adipose tissue
Review Article
030204 cardiovascular system & hematology
ADIPOKINE EXPRESSION
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Oxygen Consumption
Internal medicine
Metabolically healthy obesity
EXTRACELLULAR-MATRIX
medicine
IMPROVES INSULIN SENSITIVITY
Glucose homeostasis
Humans
Review Articles
GENE-EXPRESSION
BLOOD-FLOW
business.industry
hypoxia
MITOCHONDRIAL BIOGENESIS
medicine.disease
Lipid Metabolism
METABOLICALLY HEALTHY OBESITY
adipose tissue
BODY-MASS INDEX
Oxygen
NORMOBARIC HYPOXIA
030104 developmental biology
Endocrinology
Glucose
inflammation
medicine.symptom
Adipocyte hypertrophy
business
metabolism
Subjects
Details
- ISSN :
- 17481716
- Volume :
- 228
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Acta physiologica (Oxford, England)
- Accession number :
- edsair.doi.dedup.....3b81495775a7f543aed8928651fff0fc