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Comparison of 25 and 50 microgram of misoprostol for induction of labour in nulliparous women with postdate pregnancy in Port Harcourt
- Source :
- Nigerian Journal of Clinical Practice; Vol 18, No 2 (2015); 263-267
- Publication Year :
- 2015
-
Abstract
- Background : Induction of labor for postdate pregnancy using misoprostol is one of the most common interventions in pregnancy. However, the optimal dose of misoprostol is yet to be determined with previous reports utilizing different dosages. Objective : The main objective of this study was to compare the effectiveness and safety of 25 μg versus 50 μg of intravaginal misoprostol for induction of labor in nulliparous women with postdate pregnancy. Methodology : This was a prospective study in which 88 nulliparous women with postdate pregnancy were randomly selected to receive either 25 μg or 50 μg of misoprostol for induction of labor. Student’s t‑test and Chi‑square test were used to compare proportions. Results : There was no significant difference between the two groups with regard to the induction‑vaginal delivery interval between the two doses. The proportion of women delivering vaginally with a single dose of misoprostol (11/40 vs. 23/43, P = 0.01) and vomiting were significantly greater in the 50 μg group. However, there was no significant difference between both groups in terms of the need for augmentation of labor, caesarean section, tachysystole and hyperstimulation syndrome. Conclusion : Intravaginal administration of 25 μg of misoprostol appears to be as effective, but safer than 50 μg for induction of labor in nulliparous women with postdate pregnancy. Key words : Induction of labor, misoprostol, Port Harcourt, postdate pregnancy
- Subjects :
- Adult
medicine.medical_specialty
Microgram
medicine.medical_treatment
Nigeria
law.invention
Randomized controlled trial
law
Pregnancy
Oxytocics
medicine
Humans
Caesarean section
Pregnancy, Prolonged
Induction of labor, misoprostol, Port Harcourt, postdate pregnancy
Labor, Induced
Prospective Studies
Prospective cohort study
Misoprostol
Gynecology
Dose-Response Relationship, Drug
Obstetrics
business.industry
Cesarean Section
Pregnancy Outcome
General Medicine
medicine.disease
Delivery, Obstetric
Administration, Intravaginal
Parity
Vomiting
Intravaginal administration
Female
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 11193077
- Volume :
- 18
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Nigerian journal of clinical practice
- Accession number :
- edsair.doi.dedup.....3b88e9842647ee86b9fe4177b546b635