Effect of inherent misalignment and head motion in neurological PET/MR with the Philips Ingenuity TF – phantom and patient study

The aim of the study was to evaluate the effect of misalignment and head motion on image quantification in PET/MR with a novel brain phantom and a healthy control group. The phantom was imaged at two time points in PET/MR, concurrently with PET and PET/CT. Phantom images were evaluated visually and the relative difference in hemispheric accumulation was calculated. Difference in cortical accumulation in a healthy control group was evaluated from non-attenuation corrected (NAC) and MR attenuation corrected (MRAC) images. Regional ROI mean values from F18-FDG ratio images and regional hemispheric asymmetries were calculated. Controls were divided to high and low asymmetry groups. A student’s t-test (p