Inhibition of chondroitin sulphate and heparin on the growth and agglomeration of calcium oxalate monohydrate crystals in vitro

Seed experiments on the growth of calcium oxalate monohydrate in vitro have given the following results. Chondroitin sulphate does not influence the growth but only the agglomeration. The main influence of heparin at all concentrations is to inhibit the agglomeration, but at concentrations greater than about 10−8 mol/l the growth is also inhibited. In the range 0.05–30 μmol/l there is a linear dependence between the percentage inhibition of the growth and the concentration of heparin.