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Renal Tubular Acidosis

Authors :
Aditi Sinha
Arvind Bagga
Source :
The Indian Journal of Pediatrics. 87:733-744
Publication Year :
2020
Publisher :
Springer Science and Business Media LLC, 2020.

Abstract

Renal tubular acidosis (RTA) comprises a group of disorders characterized by low capacity for net acid excretion and persistent hyperchloremic metabolic acidosis, despite preserved glomerular filtration rate. RTA are classified into chiefly three types (1, 2 and 4) based on pathophysiology and clinical and laboratory characteristics. Most patients have primary RTA that presents in infancy with polyuria, growth retardation, rickets and/or hypotonia. Diagnosis requires careful evaluation, including exclusion of other entities that can cause acidosis. A variety of tests, administered stepwise, are useful for the diagnosis and characterization of RTA. A genetic or acquired basis can be determined in majority of patients through focused evaluation. Management involves correction of acidosis and dyselectrolytemia; patients with proximal RTA with Fanconi syndrome and rickets require additional supplements of phosphate and vitamin D.

Details

ISSN :
09737693 and 00195456
Volume :
87
Database :
OpenAIRE
Journal :
The Indian Journal of Pediatrics
Accession number :
edsair.doi.dedup.....3bba02009e252508eaac9e6fc7e3d93f
Full Text :
https://doi.org/10.1007/s12098-020-03318-8