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Impact of glycemic control on the association of endothelial dysfunction and coronary artery disease in patients with type 2 diabetes mellitus

Authors :
Weifeng Shen
Yong-Hua Liu
Xiaoqun Wang
Lin Lu
Shuai Chen
Le-Ying Li
C.D Yang
Fenghua Ding
Li-Ping Zhang
Yang Dai
Ri Ji
Zhi-Ming Wu
Ying Shen
Jing-Meng Liu
Source :
Cardiovascular Diabetology, Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-9 (2021)
Publication Year :
2021
Publisher :
BioMed Central, 2021.

Abstract

Background We investigated whether glycemic control affects the relation between endothelial dysfunction and coronary artery disease in patients with type 2 diabetes mellitus (T2DM). Methods In 102 type 2 diabetic patients with stable angina, endothelial function was evaluated using brachial artery flow-mediated dilation (FMD) with high-resolution ultrasound, and significant stenosis of major epicardial coronary arteries (≥ 50% diameter narrowing) and degree of coronary atherosclerosis (Gensini score and SYNTAX score) were determined. The status of glycemic control was assessed by blood concentration of glycated hemoglobin (HbA1c). Results The prevalence of significant coronary artery stenosis (67.9% vs. 37.0%, P = 0.002) and degree of coronary atherosclerosis (Gensini score: 48.99 ± 48.88 vs. 15.07 ± 21.03, P 0.05). Conclusion Poor glycemic control negatively influences the association of endothelial dysfunction and coronary artery disease in T2DM patients.

Details

Language :
English
ISSN :
14752840
Volume :
20
Database :
OpenAIRE
Journal :
Cardiovascular Diabetology
Accession number :
edsair.doi.dedup.....3bbaff883056ae708f6149c5397c2d42