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Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy

Authors :
Magda Heras
Carlos Hermenegildo
Julio Núñez
Angel Ois
Miguel A. Valverde
Ander Regueiro
Elisa Cuadrado-Godia
Maribel Díaz-Ricard
Jaume Marrugat
Juan Sanchis
Jaume Roquer
Gines Escolar
Susana Novella
Eva Giralt-Steinhauer
Anna Oliveras
Source :
PLoS ONE, Vol 10, Iss 9, p e0132415 (2015), Cuadrado Godia, Elisa Regueiro, Ander Núñez Villota, Julio Díaz Ricard, Maribel Novella del Campo, Susana Oliveras, Anna Valverde, Miguel A. Marrugat, Jaume Ois, Angel Giralt-Steinhauer, Eva Sanchís, Juan Escolar, Ginés Hermenegildo, Carlos Heras, Magda Roquer, Jaume 2015 Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy. Plos One 10 9 e0132415, RODERIC. Repositorio Institucional de la Universitat de Valéncia, instname, RODERIC: Repositorio Institucional de la Universitat de Valéncia, PLoS ONE, Recercat. Dipósit de la Recerca de Catalunya
Publication Year :
2015
Publisher :
Public Library of Science (PLoS), 2015.

Abstract

INTRODUCTION: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute myocardial infarction (AMI) or atherothrombotic stroke (AS). We were interested in the prognostic role of endothelial progenitor cells (EPC) and circulating endothelial cells (CEC). METHODS: Between February 2009 and July 2012, 100 AMI and 50 AS patients were consecutively studied in three Spanish centres. Patients with previously documented coronary artery disease or ischemic strokes were excluded. Samples were collected within 24h of onset of symptoms. EPC and CEC were studied using flow cytometry and categorized by quartiles. Patients were followed for up to 6 months. NVE was defined as new acute coronary syndrome, transient ischemic attack (TIA), stroke, or any hospitalization or death from cardiovascular causes. The variables included in the analysis included: vascular risk factors, carotid intima-media thickness (IMT), atherosclerotic burden and basal EPC and CEC count. Multivariate survival analysis was performed using Cox regression analysis. RESULTS: During follow-up, 19 patients (12.66%) had a new vascular event (5 strokes; 3 TIAs; 4 AMI; 6 hospitalizations; 1 death). Vascular events were associated with age (P = 0.039), carotid IMT≥0.9 (P = 0.044), and EPC count (P = 0.041) in the univariate analysis. Multivariate Cox regression analysis showed an independent association with EPC in the lowest quartile (HR: 10.33, 95%CI (1.22-87.34), P = 0.032] and IMT≥0.9 [HR: 4.12, 95%CI (1.21-13.95), P = 0.023]. CONCLUSIONS: Basal EPC and IMT≥0.9 can predict future vascular events in patients with AMI and AS, but CEC count does not affect cardiovascular risk This study was supported in part bySpain’s Ministry of Health (Ministerio de Sanidad y Consumo, FONDO DE INVESTIGACIÓN SANITARIA, Instituto de Salud Carlos III. Grant number: PI080459, RED DE INVESTIGACIÓN/nCARDIOVASCULAR (RIC RD12/0042/0010, RIC RD12/0042/0052, RD12/0042/0020).

Details

Language :
English
ISSN :
19326203
Volume :
10
Issue :
9
Database :
OpenAIRE
Journal :
PLoS ONE
Accession number :
edsair.doi.dedup.....3bcdbd7e34b2159452ebe248092d92cf