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Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target
- Source :
- Canadian Journal of Gastroenterology & Hepatology, Canadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- Immunological disorders, increased oxidative stress, and damage to the epithelial barrier play an important role in the pathogenesis of inflammatory bowel diseases (IBDs). In the treatment of patients with Crohn’s disease (CD) and ulcerative colitis (UC), it is increasingly common to use biological drugs that selectively affect individual components of the inflammatory cascade. However, administering the medicines currently available does not always result in obtaining and maintaining remission, and it may also lead to the development of resistance to a given agent over time. Metallothioneins (MTs) belong to the group of low molecular weight proteins, which, among others, regulate the inflammation and homeostasis of heavy metals as well as participating in the regulation of the intensity of oxidative stress. The results of the studies conducted so far do not clearly indicate the role of MTs in the process of inflammation in patients with IBD. However, there are reports that suggest the possibility of using MTs as a potential target in the treatment of this group of patients.
- Subjects :
- Inflammation
RC799-869
Review Article
Disease
medicine.disease_cause
Pathogenesis
Crohn Disease
Humans
Medicine
Hepatology
business.industry
Gastroenterology
Inflammatory Bowel Diseases
Heavy metals
General Medicine
Diseases of the digestive system. Gastroenterology
medicine.disease
Ulcerative colitis
Oxidative Stress
Immunology
Colitis, Ulcerative
Metallothionein
medicine.symptom
business
Oxidative stress
Homeostasis
Subjects
Details
- ISSN :
- 22912797 and 22912789
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Canadian Journal of Gastroenterology and Hepatology
- Accession number :
- edsair.doi.dedup.....3bcf120c0267fe8924b1421ea979408c