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Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections
- Source :
- Experimental Parasitology. 126:91-96
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- New more efficacious antimicrobials as required for the treatment of Acanthamoeba infections as those currently available require arduous treatment regimes, are not always effective and are poorly active against the cystic stages. Herein, we review potential drug targets including tubulin, alternative oxidase, amino acid biosynthesis and myosin. In addition, we review the literature for current missing tools and resources for the identification, validation and development of new antimicrobials for this organism. Additional targets should come to light through a concerted genome sequencing effort.
- Subjects :
- Drug
media_common.quotation_subject
Immunology
Drug target
Antiprotozoal Agents
Acanthamoeba
Computational biology
Biology
Ornithine Decarboxylase
DNA sequencing
Microbiology
Mitochondrial Proteins
Animals
Humans
Cellulose
Organism
Plant Proteins
media_common
Medical treatment
Acanthamoeba species
Amebiasis
General Medicine
biology.organism_classification
Cytoskeletal Proteins
Disease Models, Animal
Infectious Diseases
Parasitology
Identification (biology)
Oxidoreductases
Subjects
Details
- ISSN :
- 00144894
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Experimental Parasitology
- Accession number :
- edsair.doi.dedup.....3bf59c562101379c1bf19636704e7815
- Full Text :
- https://doi.org/10.1016/j.exppara.2009.11.016