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Microstructural disruption of the right inferior fronto‐occipital and inferior longitudinal fasciculus contributes to WMH‐related cognitive impairment
- Source :
- CNS Neuroscience & Therapeutics
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Aims White matter hyperintensity (WMH) is the most common neuroimaging manifestation of cerebral small vessel disease and is related to cognitive dysfunction or dementia. This study aimed to investigate the mechanism and effective indicators to predict WMH‐related cognitive impairment. Methods We recruited 22 healthy controls (HC), 25 cases of WMH with normal cognition (WMH‐NC), and 23 cases of WMH with mild cognitive impairment (WMH‐MCI). All individuals underwent diffusion tensor imaging (DTI) and a standardized neuropsychological assessment. Automated Fiber Quantification was used to extract altered DTI metrics between groups, and partial correlation was performed to assess the associations between WM integrity and cognitive performance. Furthermore, machine learning analyses were performed to determine underlying imaging markers of WMH‐related cognitive impairment. Results Our study found that mean diffusivity (MD) values of several fiber bundles including the bilateral anterior thalamic radiation (ATR), the left inferior fronto‐occipital fasciculus (IFOF), the right inferior longitudinal fasciculus (ILF), and the right superior longitudinal fasciculus (SLF) were negatively correlated with memory function, while that of the anterior component of the right IFOF and the posterior and intermediate component of the right ILF showed significant negative correlation with MMSE and episodic memory, respectively. Furthermore, machine learning analyses showed that the accuracy of recognizing WMH‐MCI patients from the WMH populations was up to 80.5% and the intermediate and posterior components of the right ILF and the anterior component of the right IFOF contribute the most. Conclusions Changes in the properties of DTI may be the potential mechanism of WMH‐related MCI, especially the right IFOF and the right ILF, which may become imaging markers for predicting WMH‐related cognitive dysfunction.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Neuropsychological Tests
Audiology
behavioral disciplines and activities
the right inferior fronto‐occipital fasciculus
03 medical and health sciences
0302 clinical medicine
Neuroimaging
Physiology (medical)
mental disorders
Fasciculus
Humans
Medicine
Dementia
Cognitive Dysfunction
Pharmacology (medical)
the right inferior longitudinal fasciculus
Effects of sleep deprivation on cognitive performance
Inferior longitudinal fasciculus
Neuropsychological assessment
cognitive impairment
Aged
Aged, 80 and over
Pharmacology
biology
medicine.diagnostic_test
business.industry
white matter hyperintensity
Cognition
Original Articles
Middle Aged
medicine.disease
biology.organism_classification
White Matter
Frontal Lobe
Psychiatry and Mental health
Cross-Sectional Studies
Diffusion Tensor Imaging
030104 developmental biology
automated fiber quantification
Original Article
Female
Occipital Lobe
business
030217 neurology & neurosurgery
Diffusion MRI
Subjects
Details
- ISSN :
- 17555949 and 17555930
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- CNS Neuroscience & Therapeutics
- Accession number :
- edsair.doi.dedup.....3c37cc0c2438b38deced3a616bff0dbb