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VHGenes of Human Autoantibodies
- Source :
- International Reviews of Immunology. 5:253-264
- Publication Year :
- 1990
- Publisher :
- Informa UK Limited, 1990.
-
Abstract
- Important questions about pathogenic autoantibodies are whether they arise from germline V genes that contribute to the immunoglobulin repertoire in normal persons, whether they stem from “abnormal” V genes that are peculiar to patients with autoimmune diseases, and whether they are encoded by unmodified or somatically mutated immunoglobulin genes. These issues influence the way we think about three aspects of autoimmunity: genetic susceptibility to autoimmunization, the origins of lesion-producing autoantibodies, and the prevention and medical management of autoimmune disorders.
- Subjects :
- T-Lymphocytes
Molecular Sequence Data
Immunology
Immunoglobulin Variable Region
CD5 Antigens
medicine.disease_cause
Germline
Autoimmunity
Antigens, CD
Sequence Homology, Nucleic Acid
medicine
Genetic predisposition
Humans
Immunology and Allergy
Amino Acid Sequence
Autoantibodies
Genetics
Base Sequence
Genes, Immunoglobulin
biology
Immunoglobulin genes
Repertoire
Autoantibody
Vh genes
Germ Cells
Antibodies, Antinuclear
Mutation
biology.protein
Antibody
Immunoglobulin Heavy Chains
Subjects
Details
- ISSN :
- 15635244 and 08830185
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- International Reviews of Immunology
- Accession number :
- edsair.doi.dedup.....3c42aca3e77d64a55b1ca5f2567cf997