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Alternating Modulation of Subthalamic Nucleus Beta Oscillations during Stepping
- Source :
- The Journal of Neuroscience
- Publication Year :
- 2018
- Publisher :
- Society for Neuroscience, 2018.
-
Abstract
- Gait disturbances in Parkinson's disease are commonly refractory to current treatment options and majorly impair patient's quality of life. Auditory cues facilitate gait and prevent motor blocks. We investigated how neural dynamics in the human subthalamic nucleus of Parkinsons's disease patients (14 male, 2 female) vary during stepping and whether rhythmic auditory cues enhance the observed modulation. Oscillations in the beta band were suppressed after ipsilateral heel strikes, when the contralateral foot had to be raised, and reappeared after contralateral heel strikes, when the contralateral foot rested on the floor. The timing of this 20–30 Hz beta modulation was clearly distinct between the left and right subthalamic nucleus, and was alternating within each stepping cycle. This modulation was similar, whether stepping movements were made while sitting, standing, or during gait, confirming the utility of the stepping in place paradigm. During stepping in place, beta modulation increased with auditory cues that assisted patients in timing their steps more regularly. Our results suggest a link between the degree of power modulation within high beta frequency bands and stepping performance. These findings raise the possibility that alternating deep brain stimulation patterns may be superior to constant stimulation for improving parkinsonian gait.SIGNIFICANCE STATEMENTGait disturbances in Parkinson's disease majorly reduce patients' quality of life and are often refractory to current treatment options. We investigated how neural activity in the subthalamic nucleus of patients who received deep brain stimulation surgery covaries with the stepping cycle. 20–30 Hz beta activity was modulated relative to each step, alternating between the left and right STN. The stepping performance of patients improved when auditory cues were provided, which went along with enhanced beta modulation. This raises the possibility that alternating stimulation patterns may also enhance beta modulation and may be more beneficial for gait control than continuous stimulation, which needs to be tested in future studies.
- Subjects :
- Male
0301 basic medicine
Deep brain stimulation
Parkinson's disease
Deep Brain Stimulation
Feedback, Psychological
medicine.medical_treatment
Stimulation
Walking
freezing of gait
stepping-related STN activity
03 medical and health sciences
0302 clinical medicine
Rhythm
Gait (human)
Subthalamic Nucleus
Neurobiology of Disease
Humans
Medicine
Beta (finance)
Gait
Research Articles
Aged
auditory cueing
Gait Disturbance
business.industry
General Neuroscience
Parkinson Disease
Middle Aged
medicine.disease
Biomechanical Phenomena
Electrodes, Implanted
beta modulation
Subthalamic nucleus
030104 developmental biology
Acoustic Stimulation
Female
Heel
Cues
Beta Rhythm
business
Neuroscience
Psychomotor Performance
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....3c4a9dee0a73acf46fe57404739fae4d
- Full Text :
- https://doi.org/10.1523/jneurosci.3596-17.2018