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Noninvasive assessment of left atrial fibrosis. Correlation between echocardiography, biomarkers, and electroanatomical mapping
- Source :
- Echocardiography. 35:1326-1334
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- AIM Left atrial (LA) fibrosis promotes atrial fibrillation (AF), may predict poor radiofrequency catheter ablation (RFCA) outcome, and may be assessed invasively using electroanatomical mapping (EAM). Speckle tracking echocardiography (STE) enables quantitative assessment of LA function. The aim was to assess the relationship between LA fibrosis derived from EAM and LA echocardiographic parameters as well as biomarkers of fibrosis in patients with AF. METHODS Sixty-six patients (64% males, mean age 56 ± 10) with nonvalvular AF treated with first RFCA were prospectively studied. Seventy-three percent of patients were in sinus rhythm at the time of examination. LA geometry, systolic, and diastolic function were assessed. In STE global, peak atrial longitudinal (PALS) and contractile (PACS) strain were calculated. LA stiffness index (LAs) - the ratio of E/e' to PALS - was assessed. The EAM of LA was build using Carto System before RFCA. Low amplitude potentials area (LAPA) was quantitatively analyzed and expressed as a percentage of LA surface using the cut-off
- Subjects :
- Male
Electroanatomic mapping
medicine.medical_specialty
Diastole
Speckle tracking echocardiography
030204 cardiovascular system & hematology
Transforming Growth Factor beta1
Correlation
03 medical and health sciences
0302 clinical medicine
Fibrosis
Left atrial
Internal medicine
Atrial Fibrillation
medicine
Humans
Radiology, Nuclear Medicine and imaging
Sinus rhythm
Heart Atria
Prospective Studies
030212 general & internal medicine
business.industry
Atrial fibrillation
Middle Aged
medicine.disease
Peptide Fragments
Matrix Metalloproteinase 9
Echocardiography
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Procollagen
Subjects
Details
- ISSN :
- 07422822
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Echocardiography
- Accession number :
- edsair.doi.dedup.....3c5950db6411a83923a1da4b5cf67cf8