PcMtr, an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum

Authors :: Hein Trip
Arnold J. M. Driessen
Melchior E. Evers
Molecular Microbiology
Groningen Biomolecular Sciences and Biotechnology
Molecular Genetics
Faculty of Science and Engineering
Source :: Biochimica et Biophysica Acta-Biomembranes, 1667(2), 167-173. Elsevier
Publication Year :: 2004
Publisher :: Elsevier BV, 2004.
Abstract: The gene encoding an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum was cloned, functionally expressed and characterized in Saccharomyces cerevisiae M4276. The permease, designated PcMtr, is structurally and functionally homologous to Mtr of Neurospora crassa, and unrelated to the Amino Acid Permease (AAP) family which includes most amino acid permeases in fungi. Database searches of completed fungal genome sequences reveal that Mtr type permeases are not widely distributed among fungi, suggesting a specialized function. (C) 2004 Elsevier B.V. All rights reserved.

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