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T2 Mapping and Fat Quantification of Thigh Muscles in Children with Duchenne Muscular Dystrophy
- Source :
- Current Medical Science. 39:138-145
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Quantitative magnetic resonance image (MRI) in individual muscles may be useful for monitoring disease progression in Duchenne muscular dystrophy (DMD). The purpose of this study was to measure T2 relaxation time of thigh muscles in children with DMD and healthy boys, and to correlate the T2 relaxation time of muscles with the fat fraction (FF) at quantitative magnetic resonance and results of clinical assessment. Thirty-two boys with DMD and 18 healthy boys were evaluated with T2 mapping and three-point Dixon MRI. Age, body mass index (BMI), muscle strength assessment, timed functional tests (time to walk or run 10 metres, rise from the floor and ascend four stairs), and the North Star Ambulatory Assessment (NSAA) were evaluated. Spearman's correlation was used to assess the relationships between FF and clinical assessments and T2 relaxation time. The mean T2 relaxation time of thigh muscles in DMD was significantly longer than that in the control group (P
- Subjects :
- Male
musculoskeletal diseases
medicine.medical_specialty
Adolescent
T2 mapping
Duchenne muscular dystrophy
Fat quantification
Biochemistry
Body Mass Index
Internal medicine
Genetics
medicine
Humans
Prospective Studies
Child
Muscle, Skeletal
medicine.diagnostic_test
business.industry
Thigh muscle
Skeletal muscle
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Muscular Dystrophy, Duchenne
medicine.anatomical_structure
Adipose Tissue
Thigh
Case-Control Studies
Child, Preschool
Ambulatory
Disease Progression
Cardiology
business
Body mass index
Subjects
Details
- ISSN :
- 2523899X and 20965230
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Current Medical Science
- Accession number :
- edsair.doi.dedup.....3c60388e292200d9a60efeb1588c195b