Supplementary Figures 1-8 from β-Catenin/POU5F1/SOX2 Transcription Factor Complex Mediates IGF-I Receptor Signaling and Predicts Poor Prognosis in Lung Adenocarcinoma

Supplementary Figures 1-8 PDF file 1850K, Supplementary Figure 1. LACSLCs derived from A549 and H358 cell lines; Supplementary Figure 2. Sphere LACSLCs derived from A549 cell line expressed high levels of CSLCs transcription factors including SOX2 and POU5F1 with low expression of differentiated markers CK8/CK18;Supplementary Figure 3. Immunofluorescence staining of CD133 and ALDH1A1;Supplementary Figure 4. Correlation of IGF-1R and ALDH1A1 with poor DSS in LAC patients;Supplementary Figure 5. Insulin signaling/IGF pathway is highly correlated with expression genes in LACSLCs;Supplementary Figure 6. Disruption of IGF-1R signaling pathway inhibits the self-renewal and the tumorigenic potential of human LACSLCs;Supplementary Figure 7. MEK inhibitor PD98059 has no effect on POU5F1; Expression of IGF-1, �-catenin and POU5F1 in fresh LAC specimens and A549 LACSLCs