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Suppressive action of near-ultraviolet light on ouabain resistance induced by far-ultraviolet light in Chinese hamster cells
- Source :
- Mutation Research Letters. 119:399-406
- Publication Year :
- 1983
- Publisher :
- Elsevier BV, 1983.
-
Abstract
- The interaction between ultraviolet light (UV-C) from germicidal lamps (254 nm) and near-ultraviolet light (UV-B) from Westinghouse Sun Lamps (290-345 nm) was studied in Chinese hamster V79 cells by measuring the effectiveness of combined exposures to induce the resistance to 6-thioguanine or to ouabain. Exposure of cells to a conditioning dose of UV-B (approximately 70% survival) results in significant inhibition of the induction by UV-C of cells resistant to ouabain. The inhibition is lost, however, if cells are incubated for 12 h at 37 degrees C between exposures. Inhibition is also observed when cells are preirradiated with a dose of UV-B filtered with polystyrene (300-345 nm) which, in itself, has no effect on cell killing. Conditioning exposures of unfiltered or filtered UV-B light do not inhibit the induction of 6-thioguanine-resistant cells by UV-C light, and the effects of UV-B and UV-C light are largely independent.
- Subjects :
- biology
Ultraviolet Rays
Chemistry
Far ultraviolet
Drug Resistance
OUABAIN RESISTANCE
General Medicine
V79 cells
biology.organism_classification
Chinese hamster
Ouabain
Toxicology
Cricetulus
Cell killing
Cricetinae
Biophysics
medicine
Ultraviolet light
Animals
Polystyrenes
Near ultraviolet
Thioguanine
Cells, Cultured
medicine.drug
Subjects
Details
- ISSN :
- 01657992
- Volume :
- 119
- Database :
- OpenAIRE
- Journal :
- Mutation Research Letters
- Accession number :
- edsair.doi.dedup.....3c9dc2ee0b66c74b78c5d0720c3e7481
- Full Text :
- https://doi.org/10.1016/0165-7992(83)90192-6