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From melanocytes to melanomas
- Source :
- Nature reviews. Cancer. 16(6)
- Publication Year :
- 2016
-
Abstract
- Melanomas on sun-exposed skin are heterogeneous tumours, which can be subtyped on the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic neoplasm can also be staged by how far it has progressed, ranging from a benign neoplasm, such as a naevus, to a malignant neoplasm, such as a metastatic melanoma. Each subtype of melanoma can evolve through distinct evolutionary trajectories, passing through (or sometimes skipping over) various stages of transformation. This Review delineates several of the more common progression trajectories that occur in the patient setting and proposes models for tumour evolution that integrate genetic, histopathological, clinical and biological insights from the melanoma literature.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Metastatic melanoma
Applied Mathematics
General Mathematics
Melanoma
food and beverages
Melanocytic neoplasm
Biology
medicine.disease
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
030220 oncology & carcinogenesis
Cancer genetics
Mutation
medicine
Neoplasm
Nevus
Humans
Melanocytes
Neoplasm staging
Subjects
Details
- ISSN :
- 14741768
- Volume :
- 16
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Nature reviews. Cancer
- Accession number :
- edsair.doi.dedup.....3c9f6eb2680b0199cc78fcb5f29e2c9c