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Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group
- Source :
- PLoS ONE, Vol 13, Iss 10, p e0206389 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- Changes in levels of cytokines and chemokines have been proposed as possible biomarkers of tissue injury, including liver injury due to drugs. Recently, in acute drug-induced liver injury (DILI), we showed that 19 of 27 immune analytes were differentially expressed and that disparate patterns of immune responses were evident. Lower values of serum albumin (< 2.8 g/dL) and lower levels of only four analytes, namely, IL-9, IL-17, PDGF-bb, and RANTES, were highly predictive of early death [accuracy = 96%]. The goals of this study were to assess levels of the same 27 immune analytes in larger numbers of subjects to learn whether the earlier findings would be confirmed in new and larger cohorts of subjects, compared with a new cohort of healthy controls. We studied 127 subjects with acute DILI enrolled into the US DILIN. We also studied 118 subjects with severe acute liver injury of diverse etiologies, enrolled into the ALF SG registry of subjects. Controls comprised 63 de-identified subjects with no history of liver disease and normal liver tests. Analytes associated with poor outcomes [death before 6 months, n = 32 of the total of 232 non-acetaminophen (Apap) subjects], were lower serum albumin [2.6 vs 3.0 g/dL] and RANTES [6,458 vs 8,999 pg/mL] but higher levels of IL-6 [41 vs 18], IL-8 [78 vs 48], and MELD scores [30 vs 24]. Similar patterns were observed for outcome of death/liver transplant within 6 months. A model that included only serum albumin < 2.8 g/dL and RANTES below its median value of 11,349 had 83% (or 81%) accuracy for predicting early death (or early death/liver transplant) in 127 subjects from DILIN. No patterns of serum immune analytes were reflective of the etiologies of acute liver failure, but there were cytokine patterns that predicted prognosis in both acute DILI and ALF.
- Subjects :
- 0301 basic medicine
Etiology
Physiology
Gastroenterology and hepatology
medicine.medical_treatment
lcsh:Medicine
Liver transplantation
Pathology and Laboratory Medicine
Biochemistry
Gastroenterology
Hepatitis
Liver disease
0302 clinical medicine
Immune Physiology
Medicine and Health Sciences
lcsh:Science
Liver injury
Innate Immune System
Multidisciplinary
biology
Fatty liver
Hepatitis B
3. Good health
Infectious hepatitis
Cytokine
Cohort
Cytokines
Infectious diseases
030211 gastroenterology & hepatology
Research Article
medicine.medical_specialty
Immunology
Acute Liver Failure
Serum albumin
Surgical and Invasive Medical Procedures
Viral diseases
Digestive System Procedures
03 medical and health sciences
Albumins
Internal medicine
medicine
Serum Albumin
Liver diseases
Transplantation
business.industry
lcsh:R
Biology and Life Sciences
Proteins
Organ Transplantation
Molecular Development
medicine.disease
Liver Transplantation
Fatty Liver
030104 developmental biology
Immune System
biology.protein
lcsh:Q
business
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....3cbb8c0f713b1041e01ee2180c5d702e