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Characterization of Soybean Germinated Embryo Extract as an Estrogen Receptor Subtype-Selective and Tissue-Specific Modulator
Characterization of Soybean Germinated Embryo Extract as an Estrogen Receptor Subtype-Selective and Tissue-Specific Modulator
- Source :
- Journal of medicinal food. 22(2)
- Publication Year :
- 2018
-
Abstract
- Phytoestrogens possess beneficial effects in the management of menopausal symptoms with few side effects. Soybeans are major natural sources of isoflavones, with high estrogen receptor (ER)-β selectivity. The objective of this study therefore was to develop a solvent-mediated extraction method for soybean germinated embryos (SGEs) and to investigate the biological activities of the extract. Ethanolic extraction yielded the SGE extract (SGEE), which had a unique composition of biologically active aglycones and soyasaponins. SGEE showed a proliferative effect in MCF7 cells and ERβ-selective transcriptional activities in human embryonic kidney cells. In addition, oral administration of SGEE to ovariectomized rats resulted in the induction of ERβ and estrogen-responsive genes in the uterus and a decrease in tail skin temperature and uterus weight. Our data suggest that germination and ethanolic extraction are effective measures for producing isoflavone-rich food supplements, which may be useful as alternative menopausal hormone therapy.
- Subjects :
- 0301 basic medicine
Selective Estrogen Receptor Modulators
Tail
Ovariectomy
Uterus
Medicine (miscellaneous)
Estrogen receptor
Germination
Phytoestrogens
Pharmacology
Body Temperature
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Oral administration
medicine
Animals
Estrogen Receptor beta
Humans
Skin
030109 nutrition & dietetics
Nutrition and Dietetics
Plant Extracts
Embryo
Biological activity
Organ Size
Isoflavones
Saponins
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
Seeds
Ovariectomized rat
MCF-7 Cells
Female
Soybeans
Menopause
Phytotherapy
Subjects
Details
- ISSN :
- 15577600
- Volume :
- 22
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of medicinal food
- Accession number :
- edsair.doi.dedup.....3cd10a7558af0a256e7a1397f56b0bde