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Characterization of Soybean Germinated Embryo Extract as an Estrogen Receptor Subtype-Selective and Tissue-Specific Modulator

Characterization of Soybean Germinated Embryo Extract as an Estrogen Receptor Subtype-Selective and Tissue-Specific Modulator

Authors :
Hwasun Yang
Soolin Kim
Jimin Lee
Johann Sohn
Sujeong Park
Minsun Chang
Byoung Ha Ahn
Woo Duck Seo
Hyun Cheol Jeong
Sung-Jin Lee
Chang-Young Jang
Hyesoo Jeong
Sun Lim Kim
Source :
Journal of medicinal food. 22(2)
Publication Year :
2018

Abstract

Phytoestrogens possess beneficial effects in the management of menopausal symptoms with few side effects. Soybeans are major natural sources of isoflavones, with high estrogen receptor (ER)-β selectivity. The objective of this study therefore was to develop a solvent-mediated extraction method for soybean germinated embryos (SGEs) and to investigate the biological activities of the extract. Ethanolic extraction yielded the SGE extract (SGEE), which had a unique composition of biologically active aglycones and soyasaponins. SGEE showed a proliferative effect in MCF7 cells and ERβ-selective transcriptional activities in human embryonic kidney cells. In addition, oral administration of SGEE to ovariectomized rats resulted in the induction of ERβ and estrogen-responsive genes in the uterus and a decrease in tail skin temperature and uterus weight. Our data suggest that germination and ethanolic extraction are effective measures for producing isoflavone-rich food supplements, which may be useful as alternative menopausal hormone therapy.

Details

ISSN :
15577600
Volume :
22
Issue :
2
Database :
OpenAIRE
Journal :
Journal of medicinal food
Accession number :
edsair.doi.dedup.....3cd10a7558af0a256e7a1397f56b0bde