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Anti-cancer activity of Annexin V in murine melanoma model by suppressing tumor angiogenesis
- Source :
- Oncotarget
- Publication Year :
- 2017
- Publisher :
- Impact Journals LLC, 2017.
-
Abstract
- Annexin V, a protein with high affinity to phosphatidylserine (PS) in a calcium dependent manner, has been widely used to probe apoptosis. Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of tumor cells undergoing apoptosis. However, far less is known about its multiple properties, especially in cancer therapies. Here we found that Annexin V had a good anti-tumor activity in murine melanomaxenograft model. Treatment with Annexin V showed significant reduction in tumor size and remarkable tumor necrosis areas. The serum level of VEGF was downregualted by Annexin V both in normal mice and mice bearing tumor, suggesting that its new role on impeding tumor angiogenesis. In Silico analysis using Oncomine database, we also found the negative correlation of AnnexinV and VEGF both in skin and melanoma. The decreased Annexin V expression shows linearity relation with the elevated VEGF expression. These data provided a possibility that Annexin V can be used as a novel angiogenesis inhibitor in tumor therapy.
- Subjects :
- 0301 basic medicine
Melanoma, Experimental
Annexin V
necrosis
03 medical and health sciences
chemistry.chemical_compound
Mice
Random Allocation
0302 clinical medicine
Annexin
Medicine
Animals
Annexin A5
Neovascularization, Pathologic
business.industry
Melanoma
apoptosis
Cancer
Phosphatidylserine
tumor angiogenesis
medicine.disease
Angiogenesis inhibitor
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
Oncology
chemistry
Apoptosis
030220 oncology & carcinogenesis
Immunology
Cancer research
Tumor necrosis factor alpha
Female
business
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 19492553
- Volume :
- 8
- Issue :
- 26
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....3cd28e9ccbc3f68dcfa0353f55f4c8ed