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Celecoxib as a Potential Treatment for Intractable Lymphatic Malformation
- Source :
- Pediatrics. 144
- Publication Year :
- 2019
- Publisher :
- American Academy of Pediatrics (AAP), 2019.
-
Abstract
- Lymphatic malformation (LM) is a congenital disorder resulting from an abnormal development of lymphatic vessels. LM may result in problems of cosmesis and functional impairment, including airway compression. An 11-year-old girl was referred to our department with increasing dysphagia caused by a large left cervical LM with a long history of treatment. Because of the LM location, surgical resection was not an option, and various therapies, including use of picibanil, had proven ineffective. Celecoxib treatment (100 mg/day) was initiated for local pain management. Softening of the lesion was observed 2 weeks after treatment initiation, and the dose was increased to 200 mg/day with additional shrinking of the LM over the next 2 weeks. With parental consent, celecoxib was continued, with a 65% reduction in volume achieved at 6 months. The patient discontinued treatment at 12 months, and the LM volume increased. Control over the LM was achieved with resumption of celecoxib treatment. After 2 years of treatment, the LM persists, but the size of the malformation is significantly smaller. No adverse effects of celecoxib treatment were observed. The anti–cyclooxygenase-2 effect of celecoxib prevented lymphatic vessel growth through an inhibition of cyclooxygenase-2 activity in the conversion of prostaglandin to prostaglandin E2. In conclusion, celecoxib may be a promising therapeutic agent for LM management.
- Subjects :
- medicine.medical_specialty
Urology
Prostaglandin
Medication Adherence
Lesion
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Recurrence
030225 pediatrics
medicine
Lymphatic vessel
Humans
Prostaglandin E2
Child
Adverse effect
Lymphatic Abnormalities
Cyclooxygenase 2 Inhibitors
business.industry
Cosmesis
Magnetic Resonance Imaging
Airway Obstruction
Lymphatic system
medicine.anatomical_structure
chemistry
Celecoxib
Pediatrics, Perinatology and Child Health
Female
medicine.symptom
Deglutition Disorders
business
medicine.drug
Subjects
Details
- ISSN :
- 10984275 and 00314005
- Volume :
- 144
- Database :
- OpenAIRE
- Journal :
- Pediatrics
- Accession number :
- edsair.doi.dedup.....3cdda578b73ad00357f7935cba84494d
- Full Text :
- https://doi.org/10.1542/peds.2019-0319