Back to Search Start Over

Regulation of WASP

Authors :
Laura M. Machesky
Robert H. Insall
Source :
Cell. 118(2):140-141
Publication Year :
2004
Publisher :
Elsevier BV, 2004.

Abstract

Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, Ho et al. (2004) show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP. This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility.

Details

ISSN :
00928674
Volume :
118
Issue :
2
Database :
OpenAIRE
Journal :
Cell
Accession number :
edsair.doi.dedup.....3ce73761d0f75d8d3ce3c4b053dd81bd
Full Text :
https://doi.org/10.1016/j.cell.2004.07.005