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Increased expression of high mobility group box protein 1 and vascular endothelial growth factor in placenta previa
- Source :
- Molecular Medicine Reports. 16:9051-9059
- Publication Year :
- 2017
- Publisher :
- Spandidos Publications, 2017.
-
Abstract
- Placenta previa is often associated with preterm delivery, reduced birth weight, a higher frequency of placental accreta and postpartum haemorrhage, and increased likelihood of blood transfusion. The present study aimed to examine the expression of high mobility group box protein 1 (HMGB1) in the placenta of women with or without placenta previa. The study group consisted of placental tissues obtained from women with or without placenta previa. The expression levels of HMGB1 and vascular endothelial growth factor (VEGF) were evaluated in the placental tissues using reverse transcription‑quantitative polymerase chain reaction, western blotting and immunohistochemistry. The mRNA expression levels of HMGB1 and VEGF were significantly increased in the placenta previa group compared with in the normal group. In addition, the placenta previa group exhibited increased HMGB1 and VEGF staining in vascular endothelial cells and trophoblasts. There were no significant differences in the expression of HMGB1 or VEGF between groups with or without placenta accreta or postpartum haemorrhage. The present study hypothesised that the increased expression of HMGB1 in the placenta may be associated with the pathogenesis of placenta previa by regulating the expression of the proangiogenic factor VEGF.
- Subjects :
- Adult
Vascular Endothelial Growth Factor A
0301 basic medicine
Cancer Research
medicine.medical_specialty
Placenta accreta
Placenta
Placenta Previa
chemical and pharmacologic phenomena
Biology
HMGB1
Biochemistry
Andrology
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Genetics
medicine
Humans
RNA, Messenger
HMGB1 Protein
Molecular Biology
reproductive and urinary physiology
Demography
Gynecology
medicine.disease
Immunohistochemistry
Placenta previa
Vascular endothelial growth factor
030104 developmental biology
medicine.anatomical_structure
Gene Expression Regulation
Oncology
chemistry
030220 oncology & carcinogenesis
embryonic structures
biology.protein
Molecular Medicine
Female
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....3cef1959f62247023fec866489e997d4