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The Tacaribe arenavirus small zinc finger protein is required for both mRNA synthesis and genome replication

Authors :
Daniel Kolakofsky
Sylvie Rochat
Dominique Garcin
Source :
Journal of Virology, Vol. 67, No 2 (1993) pp. 807-12
Publication Year :
1993
Publisher :
American Society for Microbiology, 1993.

Abstract

An antiserum to a peptide of the Tacaribe virus Z protein was used to determine whether this small Zn(2+)-binding protein was required for viral RNA synthesis in infected cell extracts. Specific immunodepletion of the extracts invariably reduced genome synthesis to near background levels, but strong effects on mRNA synthesis occurred only early in the infection or when mRNA synthesis was relatively weak. Our results suggest that the Z protein is required for both mRNA and genome synthesis, but in somewhat different manners.

Details

ISSN :
10985514 and 0022538X
Volume :
67
Database :
OpenAIRE
Journal :
Journal of Virology
Accession number :
edsair.doi.dedup.....3d04f059d7abfd1c8f8aba9840847196