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Image‐based computational fluid dynamics for estimating pressure drop and fractional flow reserve across iliac artery stenosis: A comparison with in‐vivo measurements
- Source :
- International Journal for Numerical Methods in Biomedical Engineering. 37
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Computational Fluid Dynamics (CFD) and time‐resolved phase‐contrast magnetic resonance imaging (PC‐MRI) are potential non‐invasive methods for the assessment of the severity of arterial stenoses. Fractional flow reserve (FFR) is the current “gold standard” for determining stenosis severity in the coronary arteries but is an invasive method requiring insertion of a pressure wire. CFD derived FFR (vFFR) is an alternative to traditional catheter derived FFR now available commercially for coronary artery assessment, however, it can potentially be applied to a wider range of vulnerable vessels such as the iliac arteries. In this study CFD simulations are used to assess the ability of vFFR in predicting the stenosis severity in a patient with a stenosis of 77% area reduction (>50% diameter reduction) in the right iliac artery. Variations of vFFR, overall pressure drop and flow split between the vessels were observed by using different boundary conditions. Correlations between boundary condition parameters and resulting flow variables are presented. The study concludes that vFFR has good potential to characterise iliac artery stenotic disease.
- Subjects :
- medicine.medical_specialty
0206 medical engineering
Biomedical Engineering
Constriction, Pathologic
02 engineering and technology
Fractional flow reserve
030204 cardiovascular system & hematology
Computational fluid dynamics
Coronary Angiography
Iliac Artery
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
Molecular Biology
Pressure drop
medicine.diagnostic_test
business.industry
Applied Mathematics
Coronary Stenosis
Magnetic resonance imaging
Gold standard (test)
medicine.disease
Coronary Vessels
020601 biomedical engineering
Fractional Flow Reserve, Myocardial
Coronary arteries
Stenosis
medicine.anatomical_structure
Computational Theory and Mathematics
Modeling and Simulation
Hydrodynamics
Cardiology
business
Software
Artery
Subjects
Details
- ISSN :
- 20407947 and 20407939
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- International Journal for Numerical Methods in Biomedical Engineering
- Accession number :
- edsair.doi.dedup.....3d0938f3229da983ccb4d8b220a8f060