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Reactive oxygen species in colorectal cancer: The therapeutic impact and its potential roles in tumor progression via perturbation of cellular and physiological dysregulated pathways
- Source :
- Journal of Cellular Physiology. 234:10072-10079
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Reactive oxygen species (ROS) are produced by mitochondria during metabolism. In physiological states, the production of ROS and their elimination by antioxidants are kept in balance. However, in pathological states, elevated levels of ROS interact with susceptible cellular target compounds including lipids, proteins, and DNA and deregulate oncogenic signaling pathways that are involved in colorectal cancer (CRC) carcinogenesis. Although antioxidant compounds have been successfully used in the treatment of CRC as prevention approaches, they have also been shown in some cases to promote disease progression. In this review, we focus on the role of ROS in gastrointestinal homeostasis, CRC progression, diagnosis, and therapy with particular emphasis on ROS-stimulated pathways.
- Subjects :
- 0301 basic medicine
Antioxidant
Carcinogenesis
Physiology
Colorectal cancer
medicine.medical_treatment
Clinical Biochemistry
Mitochondrion
Biology
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
chemistry.chemical_classification
Reactive oxygen species
Cell Biology
Metabolism
medicine.disease
Oxidative Stress
030104 developmental biology
chemistry
Tumor progression
030220 oncology & carcinogenesis
Disease Progression
Cancer research
Colorectal Neoplasms
Reactive Oxygen Species
Oxidation-Reduction
Homeostasis
Signal Transduction
Subjects
Details
- ISSN :
- 10974652 and 00219541
- Volume :
- 234
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Physiology
- Accession number :
- edsair.doi.dedup.....3d12027472281a88a690b996a0dab8a3