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Diabetes mellitus is a risk factor of acute kidney injury in liver transplantation patients
- Source :
- Hepatobiliary & Pancreatic Diseases International. 20:215-221
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Diabetes mellitus has become an increasing global health burden with rapid growing prevalence. Patients with diabetes have higher susceptibility to acute kidney injury (AKI). Liver transplantation (LT) predisposes the kidney to injury. However, the association between diabetes and AKI in LT patients remains unclear. Methods We conducted a retrospective cohort study examining risk factors for AKI in patients undergone orthotopic LT. Potential risk factors including baseline estimated glomerular filtration rate (eGFR), the model for end-stage liver disease (MELD) score, diabetes, hypertension and intraoperative blood loss were screened. The primary endpoint was AKI occurrence. Multivariate logistic regression was used to analyze the association between potential risk factors and AKI. Results A total of 291 patients undergone orthotopic LT were included in the present study. Among them, 102 patients (35.05%) developed AKI within 5 days after LT. Diabetes was identified as an independent risk factor for AKI. Patients who developed AKI had worse graft function recovery and higher mortality within 14 days after LT compared to those who did not develop AKI. AKI patients with diabetes had a significant decline of eGFR within the first postoperative year, compared with patients who did not develop AKI and who developed AKI but without diabetes. Conclusions Diabetes is an independent risk factor for AKI after orthotopic LT. AKI is associated with delayed graft function recovery and higher mortality in short-term postoperative period. Diabetic patients who developed AKI after LT experience a faster decline of eGFR within the first year after surgery.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Renal function
Liver transplantation
urologic and male genital diseases
Severity of Illness Index
End Stage Liver Disease
03 medical and health sciences
Liver disease
0302 clinical medicine
Risk Factors
Internal medicine
Diabetes mellitus
Diabetes Mellitus
medicine
Clinical endpoint
Humans
Risk factor
Retrospective Studies
Hepatology
urogenital system
business.industry
Gastroenterology
Acute kidney injury
Retrospective cohort study
Acute Kidney Injury
medicine.disease
female genital diseases and pregnancy complications
Liver Transplantation
ErbB Receptors
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
business
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 14993872
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Hepatobiliary & Pancreatic Diseases International
- Accession number :
- edsair.doi.dedup.....3d1b824caae743b384a4aef707bbf17f