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Chronic obstructive pulmonary disease severity in middle-aged and older men with osteoporosis associates with decreased bone formation
- Source :
- Osteoporosis and Sarcopenia, Vol 6, Iss 4, Pp 179-184 (2020), Osteoporosis and Sarcopenia
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objectives Chronic obstructive pulmonary disease (COPD) is a risk factor for osteoporosis. Nevertheless, much remains unclear regarding the bone metabolism dynamics associated with COPD. The present study focuses on the associations between the COPD severity and serum bone metabolism biomarkers. Methods We enrolled 40 patients who visited the orthopedics departments at our institutions and underwent dual-energy X-ray absorptiometry between September 2015 and December 2017. Only male osteoporosis patients over 45 years of age were included, and 5 patients were excluded due to disease or use of internal medicines affecting bone metabolism. All subjects underwent lung function testing, spine radiography, and blood tests. We measured percent forced expiratory volume in 1 second (%FEV1), which reflects COPD severity, and we examined the relationships between %FEV1 and serum levels of bone metabolism biomarkers. Results All subjects were diagnosed with osteoporosis based on T-scores. %FEV1 correlated with body weight, body mass index (BMI), and Z-score/T-scores. %FEV1 moderately correlated with serum levels of alkaline phosphatase (ALP), procollagen type 1 N-terminal propeptide (P1NP), and tartrate-resistant acid phosphatase 5b in the partial correlation analysis adjusted for BMI or T-score in the lumbar vertebrae. We performed a hierarchical multiple regression analysis to identify that serum ALP and P1NP were the independent explanatory variables to %FEV1 independent of other factors. Conclusions The data suggest that the COPD severity in middle-aged and older men with osteoporosis associates with decreased bone formation. COPD patients may exhibit bone metabolism dynamics characterized by low bone turnover with osteogenesis dysfunction as COPD becomes severe.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
Osteoporosis
030209 endocrinology & metabolism
Lumbar vertebrae
Disease
Bone remodeling
03 medical and health sciences
0302 clinical medicine
Internal medicine
Alkaline phosphatase
medicine
Male osteoporosis
Tartrate-resistant acid phosphatase 5b
Risk factor
Procollagen type 1 N-Terminal propeptide
COPD
business.industry
Chronic obstructive pulmonary disease
medicine.disease
respiratory tract diseases
medicine.anatomical_structure
Orthopedic surgery
Original Article
030101 anatomy & morphology
lcsh:RC925-935
business
Body mass index
Subjects
Details
- ISSN :
- 24055255
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Osteoporosis and Sarcopenia
- Accession number :
- edsair.doi.dedup.....3d1ce104a606c7dc2e29576694fbd302