Back to Search
Start Over
Lesion-targeted cytology to improve cytological sampling for atypical polypoid adenomyomas of the uterus: A case series and review of the literature
- Source :
- Cytopathology : official journal of the British Society for Clinical CytologyREFERENCES. 31(6)
- Publication Year :
- 2020
-
Abstract
- Objective Atypical polypoid adenomyomas (APAs) are uncommon tumours consisting of atypical endometrioid glands and fibromyomatous stroma. Identifying the biphasic nature of atypical glandular components and spindle mesenchymal components without atypia is crucial for the cytological diagnosis of APA. We investigated the utility of lesion-targeted cytology (LTC) to directly collect firm spindle components. Methods We recruited seven consecutive surgical patients who underwent cytological examinations before surgery and were diagnosed with APA on postoperative histological examinations. Cytological smears were obtained by routine sampling in five cases and by targeted sampling using transvaginal ultrasonography, that is, LTC, in two cases. We retrospectively analysed the cytological findings from our cases and compared them to those of APA cases previously reported in the English literature. Results Among 5/7 cases that involved routine cytological sampling, normal cytological findings were found in 2 and atypical glandular cells were found in 3, but spindle cells from mesenchymal components were not detected. In contrast, among 2/7 cases in which sampling involved LTC, spindle cells without atypia, in addition to atypical glandular cells were found. Conclusions Lesion-targeted cytology is useful to assess mesenchymal components of APAs and may improve the cytological diagnosis of APA.
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Histology
Cytodiagnosis
education
Uterus
030209 endocrinology & metabolism
Pathology and Forensic Medicine
Specimen Handling
Lesion
03 medical and health sciences
Endometrium
0302 clinical medicine
Cytology
medicine
Atypia
Humans
Sampling (medicine)
Uterine Neoplasm
Ultrasonography
Vaginal Smears
Leiomyoma
business.industry
General Medicine
medicine.disease
Endometrial Neoplasms
medicine.anatomical_structure
030220 oncology & carcinogenesis
Uterine Neoplasms
Adenocarcinoma
Female
medicine.symptom
Atypical polypoid adenomyoma
business
Adenomyoma
Subjects
Details
- ISSN :
- 13652303
- Volume :
- 31
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cytopathology : official journal of the British Society for Clinical CytologyREFERENCES
- Accession number :
- edsair.doi.dedup.....3d4a4960e1693b09cce1f93737615c22