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Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes
- Source :
- Endocrine Connections, Endocrine Connections, Vol 8, Iss 4, Pp 435-441 (2019)
- Publication Year :
- 2019
-
Abstract
- Background The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial. Methods This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal examination between January 2014 and December 2015 at Shanghai First Maternity and Infant Hospital were extracted from the electronic medical records system. Thyroid-stimulating hormone (TSH), free thyroxine (fT4) and anti-thyroperoxidase autoantibody (TPO-Ab) was measured before 20 gestational weeks, and a multiple logistic regression model was used to estimate the odds ratios of pregnancy complications and neonatal outcomes between euthyroid women and those with isolated hypothyroxinaemia. Results A total of 8173 women were included in this study, of whom 342 (4.18%) were diagnosed with IMH. Regression analysis showed that IMH diagnosed in the second trimester (13–20 weeks) was associated with an increased risk of hypertensive disorders of pregnancy (OR = 2.66, 95% CI: 1.38–5.10) and placenta abruption (OR = 3.64, 95% CI: 1.07–12.41), but not with preterm delivery (OR = 1.09, 95% CI: 0.50–2.40), small or large gestational age of infant (OR = 0.91, 95% CI: 0.39–2.12; OR = 1.16, 95% CI: 0.72–1.86), macrosomia (OR = 1.71, 95% CI: 0.95–3.07), gestational diabetes mellitus (OR = 1.36, 95% CI: 0.86–2.15) and placenta previa (OR = 1.62, 95% CI: 0.39–7.37). Conclusion IMH could be a risk factor for hypertensive disorders of pregnancy.
- Subjects :
- medicine.medical_specialty
Pregnancy
lcsh:RC648-665
Obstetrics
business.industry
thyroid dysfunction
pregnancy complications
Endocrinology, Diabetes and Metabolism
Medical record
Research
hypertensive disorders of pregnancy
Retrospective cohort study
Odds ratio
hypothyroxinaemia
medicine.disease
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Placenta previa
Gestational diabetes
Endocrinology
Internal Medicine
medicine
Euthyroid
Risk factor
business
Subjects
Details
- ISSN :
- 20493614
- Volume :
- 8
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Endocrine connections
- Accession number :
- edsair.doi.dedup.....3d77be1dcbcbafa9bf8e35f84fd0500f