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Thrombotic Microangiopathy with Polymyositis/Dermatomyositis: Three Case Reports and a Literature Review
- Source :
- Internal Medicine
- Publication Year :
- 2018
- Publisher :
- Japanese Society of Internal Medicine, 2018.
-
Abstract
- Thrombotic microangiopathies (TMAs) rarely accompany polymyositis/dermatomyositis. We treated three patients with dermatomyositis combined with TMA. A literature review identified 13 previously reported cases. Exacerbation of myositis at the time of the TMA onset was observed in 62.5% of all patients, suggesting that the TMA onset may be associated with autoantibody production. We also found that cases of TMA with polymyositis/dermatomyositis often had a poor treatment response rate (37.5%). Furthermore, even if treatment was effective, the mortality rate associated with subsequent complications was high, and the survival rate was low (18.8%). Therefore, careful attention should be paid to patient management after TMA treatment.
- Subjects :
- Male
medicine.medical_specialty
Thrombotic microangiopathy
Exacerbation
Thrombotic thrombocytopenic purpura
Case Report
030204 cardiovascular system & hematology
urologic and male genital diseases
Polymyositis
Dermatomyositis
03 medical and health sciences
0302 clinical medicine
Internal Medicine
Humans
Medicine
030212 general & internal medicine
thrombotic thrombocytopenic purpura
neoplasms
Survival rate
Myositis
Thrombotic Microangiopathies
business.industry
Mortality rate
General Medicine
Middle Aged
medicine.disease
Dermatology
female genital diseases and pregnancy complications
polymyositis/dermatomyositis
Female
hemolytic-uremic syndrome
business
Subjects
Details
- ISSN :
- 13497235 and 09182918
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Internal Medicine
- Accession number :
- edsair.doi.dedup.....3d8784e1babe1413f32db05bf238a3e6
- Full Text :
- https://doi.org/10.2169/internalmedicine.0512-17