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Analysis of Choroidal Thickness in Children with Congenital Aniridia

Authors :
Xiaoyan Li
Zhuoling Lin
Jingjing Chen
Haotian Lin
Weirong Chen
Xiaohang Wu
Hui Chen
Source :
Current Eye Research. 45:1292-1297
Publication Year :
2020
Publisher :
Informa UK Limited, 2020.

Abstract

Purpose: To evaluate the choroidal thickness (CT) in children with congenital aniridia in comparison with age-matched controls. Methods: This was a cross-sectional, observational study that included 64 eyes of 32 children with congenital aniridia (aged 5-12 years) and 80 eyes of 40 healthy subjects who were age-matched. In all subjects, subfoveal choroidal thickness (SFCT) was assessed at 750-μm intervals from the fovea to 1.5 mm in the temporal and nasal directions with spectral-domain optical coherence tomography (SD-OCT). Results: The mean SFCT was 207.67 ± 30.99 µm in the aniridic eyes. This SFCT was significantly thinner than that in control eyes (288.55 ± 30.06 µm) (P < .001). The SFCTs at 1.5 mm and 0.75 mm intervals in the temporal and nasal directions from the fovea were also significantly thinner in eyes with aniridia than control eyes (P < .001).There was a significant negative correlation between the SFCT and axial length in eyes with aniridia (B = -10.60, 95%CI = -19.31~-1.89, P = .017). Conclusions: The subfoveal and parafoveal CTs were significantly thinner in eyes with congenital aniridia than in control eyes. These choroidal changes could open up a new way for the research related to the pathophysiology of congenital aniridia.

Details

ISSN :
14602202 and 02713683
Volume :
45
Database :
OpenAIRE
Journal :
Current Eye Research
Accession number :
edsair.doi.dedup.....3da96a686743694d985ee843c3e3e965