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The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin
- Source :
- eLife, eLife, Vol 10 (2021)
- Publication Year :
- 2021
- Publisher :
- eLife Sciences Publications, Ltd, 2021.
-
Abstract
- Although fear memory formation is essential for survival and fear-related mental disorders, the neural circuitry and mechanism are incompletely understood. Here, we utilized trace fear conditioning to study the formation of trace fear memory in mice. We identified the entorhinal cortex (EC) as a critical component of sensory signaling to the amygdala. We adopted both loss-of-function and gain-of-function experiments to demonstrate that release of the cholecystokinin (CCK) from the EC is required for trace fear memory formation. We discovered that CCK-positive neurons project from the EC to the lateral nuclei of the amygdala (LA), and inhibition of CCK-dependent signaling in the EC prevented long-term potentiation of the auditory response in the LA and formation of trace fear memory. In summary, high-frequency activation of EC neurons triggers the release of CCK in their projection terminals in the LA, potentiating auditory response in LA neurons. The neural plasticity in the LA leads to trace fear memory formation.
- Subjects :
- Male
Auditory Pathways
Mouse
QH301-705.5
Science
fear memory
neuroplasticity
Sensory system
Amygdala
General Biochemistry, Genetics and Molecular Biology
lateral amygdala
Mice
Memory
Neuroplasticity
medicine
Biological neural network
Animals
Fear conditioning
Biology (General)
long-term potentiation
Cholecystokinin
Neuronal Plasticity
General Immunology and Microbiology
entorhinal cortex
Chemistry
General Neuroscience
Long-term potentiation
General Medicine
Fear
Entorhinal cortex
cholecystokinin
medicine.anatomical_structure
Acoustic Stimulation
Medicine
Female
Neuroscience
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 2050084X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....3db0533811e2d4e363749608626ec169