ALS linked mutant Sigma receptor-1(E102Q) leads to disrupted RNA processing and ER stress mediated defects in protein homeostasis

Authors :: Dreser, A.
Vollrath, J. T.
Sechi, A.
Yamoah, A.
Roos, A.
Katona, I.
Bohlega, S.
Al-Saif, A.
Wiemuth, D.
Tian, Y.
Vervoorts, J.
Dohmen, M.
Aninik, J.
Troost, D.
Weis, J.
Goswami, A.
Source :: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN); 20150826-20150828; Berlin; DOC15dgnnP59 /20150825/
Publication Year :: 2015
Publisher :: German Medical Science GMS Publishing House; Düsseldorf, 2015.
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons and their target muscles. Mutant misfolded proteins, which often form intracellular inclusion bodies, are pathological hallmarks of both sporadic and familial[for full text, please go to the a.m. URL]<br />60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

Language :: English
Database :: OpenAIRE
Journal :: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN); 20150826-20150828; Berlin; DOC15dgnnP59 /20150825/
Accession number :: edsair.doi.dedup.....3dd8c1d9b95de94d3305dcf5b0049ccf
Full Text :: https://doi.org/10.3205/15dgnn83

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