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Anti-Heparin-Platelet Factor 4 Antibody is a Risk Factor for Vascular Access Obstruction in Patients Undergoing Hemodialysis
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2003
- Publisher :
- Korean Academy of Medical Sciences, 2003.
-
Abstract
- Since heparin is an anticoagulant commonly used in hemodialysis and the patients on hemodialysis are repeatedly exposed to heparin, heparin may be the cause of the development of heparin-dependent antibodies and thrombotic complications in patients on hemodialysis. The purpose of this study was to determine the prevalence and the clinical significance of the antibodies against heparin-platelet factor 4 complexes as determined by enzyme immunoassay in patients on maintenance hemodialysis. The prevalence of anti-heparin-platelet factor 4 antibodies was higher in hemodialysis patients than in normal subjects (8.8 vs 0.0%, p
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.drug_class
medicine.medical_treatment
Enzyme-Linked Immunosorbent Assay
Platelet Factor 4
Thrombophilia
Gastroenterology
Autoimmune Diseases
Catheters, Indwelling
Recurrence
Renal Dialysis
Risk Factors
Internal medicine
medicine
Humans
Risk factor
Autoantibodies
Heparin
business.industry
Anticoagulant
Autoantibody
Thrombosis
General Medicine
Middle Aged
medicine.disease
Immunology
Kidney Failure, Chronic
Female
Hemodialysis
business
Platelet factor 4
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 15986357 and 10118934
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....3ddeb6e6381f30fee0d63ab4b4c75d98