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Single nucleotide polymorphisms as genomic markers for high-throughput pharmacogenomic studies
- Source :
- Methods in Molecular Biology ISBN: 9781493931354
- Publication Year :
- 2016
- Publisher :
- Springer, 2016.
-
Abstract
- Genetic variations in patients have strong impact on their drug therapies and responses because the variations may contribute to the efficacy and/or produce undesirable side effects for any given drug. The Drug Metabolizing Enzymes and Transporters (DMET) assay is a high-throughput technology by Affymetrix that is able to simultaneously genotype variants in multiple genes involved in absorption, distribution, metabolism, and excretion of drugs for subsequent clinical applications, i.e., the assay allows for a precise genetic map that can guide therapeutic interventions and avoid side effects.
- Subjects :
- 0301 basic medicine
Drug
media_common.quotation_subject
Statistics as Topic
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
03 medical and health sciences
Genotype
Genetic variation
Genetic Marker
Genetics
Molecular Biology
Drug metabolizing enzymes and transporter
media_common
Staining and Labeling
Pharmacogenetic
Medicine (all)
Nucleic acid amplification technique
DNA
Single nucleotide polymorphism
030104 developmental biology
Genetic marker
Pharmacogenomics
Nucleic Acid Amplification Technique
Pharmacogenetics
Software
Subjects
Details
- Language :
- English
- ISBN :
- 978-1-4939-3135-4
- ISBNs :
- 9781493931354
- Database :
- OpenAIRE
- Journal :
- Methods in Molecular Biology ISBN: 9781493931354
- Accession number :
- edsair.doi.dedup.....3de1f594bb79abca62f596d2a18bdb38